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Endocrine

, Volume 4, Issue 2, pp 91–105 | Cite as

The vitamin D3 receptor in the context of the nuclear receptor superfamily

The central role of the retinoid X receptor
  • Carsten Carlberg
Review

Abstract

The nuclear hormone 1 α,25-dihydroxyvitamin D3 (VD) is an important regulator of calcium homeostasis and is also a modulator of the cell cycle. The genomic actions of the hormone are mediated by a single transcription factor, the vitamin D3 receptor (VDR). On the majority of the known VD response elements, VDR binds as heterodimeric complex with the retinoid X receptor (RXR), which is a member of the nuclear receptor superfamily like VDR. RXR supports not only the DNA binding affinity and specificity of VDR, but allosterically also its transactivation properties. Moreover RXR is a partner in other hormone response systems, which supports the idea that the different nuclear hormone signaling pathways are functionally linked.

Key Words

Regulation of transcription vitamin D receptor retinoid X receptor nuclear receptor heterodimers transactivation network of nuclear receptors 

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© Humana Press Inc 1996

Authors and Affiliations

  1. 1.Clinique de DermatologieHôpital Cantonal UniversitaireGenève 14Switzerland

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