Hepatocellular adenoma: A case with a solitary huge one surgically excised successfully

Summary

A case of hepatocellular adenoma was reported, who showed bleeding tendency, coagulation abnormalities, amenorrhea, hypertention, and albuminuria which all returned to normal negative after successful right hepatic lobectomy. Laboratory data on blood coagulation was suggstive of incrcases of Ac-globulin (Factor V, Proaccelerin) and/or fibrin-stabilizing-factor in the plasma probably released from the adenoma although they were not determined. Hypertention and albuminuria might be induced by downward displacement of the right kidney and stretching of the right renal arterties by a huge tumor, and it is most likely that this adenoma was the cause of these adnomalities: bleeding tendency and also amenorrhea.

Hepatocellular adenoma is a rare tumor of the liver, besides that with some metabolic abnormalities is extremely rare. Hepatomas accompanying some metabolic functions have been already reported as “paraneoplastic syndromes”, but none of such a case as shown here was presented. This case is probably the first one of hepatocellular adenoma with probable increases of Ac-globulin and/or fibrin-stabilizing-factor in the plasma and with some other syndromes which all disappeared after removing the adenoma.