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Effects of alcohol upon the development of liver cirrhosis induced by carbon tetrachloride

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Conclusion

The effect of 12.5% ethanol ingestion as the only source of fluid intake on cirrhosis induced in rats by the intraperitoneal injection of a 10% carbon tetrachloride solution in olive oil, (0.3 m/ per 100g body weight twice a week for 10 weeks), was studied and the follwoing results were obtained:

  1. 1)

    In the group treated with the combined use of alcohol and carbon tetrachloride, the growth of the rats was limited as compared with that of the group treated with carbon tetrachloride alone. Ten weeks after the beginning of the experiment, the difference in body weight increase between the twc groups was statistically significant.

  2. 2)

    Although the weight of the liver failed to show a significant difference between the alcohol and non-alcohol groups, the weight of the spleen was significantly heavier in the former than in the latter. The amount of lipids in the liver was the same in both groups.

  3. 3)

    The degree of hepatic fibrosis was definitely more intense in the alcohol group, suggesting the facilitating action of alcohol on the development of cirrhosis induced by carbon tetrachloride administration.

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Authors and Affiliations

  1. The First Department of Internal Medicine, School of Medicine, Kanazawa University, Takarada-machi, 13-1, Kanazawa City, Japan

    Jugoro Takeuchi, Akira Takada, Kenji Ebata, Yoshio Nakada, Genshiro Sawae & Yoshiro Okumura

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  1. Jugoro Takeuchi
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  2. Akira Takada
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  3. Kenji Ebata
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  4. Yoshio Nakada
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  5. Genshiro Sawae
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  6. Yoshiro Okumura
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Takeuchi, J., Takada, A., Ebata, K. et al. Effects of alcohol upon the development of liver cirrhosis induced by carbon tetrachloride. Gastroenterol Jpn 3, 384–389 (1968). https://doi.org/10.1007/BF02782265

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