Molecular Neurobiology

, Volume 8, Issue 2–3, pp 147–148 | Cite as

HTLV-I, infective dermatitis, and tropical spastic paraparesis

  • L. La Grenade
Neurodegenerative Diseases Part II: Transmissible Neurodegenerative Disorders (Proceedings of the symposium “Transmissible and Nontransmissible Neurodegenerative Disorders” held in Ocho Rios, Jamaica, February 28–March 5, 1993)


Since human T-cell lymphotropic virus (HTLV-I) was identified in 1980 as causing human disease, it has been etiologically associated with adult T-cell lymphoma/leukemia (ATL) and tropical spastic paraparesis (TSP). More recently, several new diseases have been reported in association with this virus, including infective dermatitis of Jamaican children, which we reported in 1990.

Studies on infective dermatitis have shown that these children have abnormalities of immune function, and some develop other HTLV-I associated disorders, including TSP. This paper reviews the work done on infective dermatitis to date, and explores the association with TSP.

Index Entries

Infective dermatitis HTLV-I TSP/HAM ATL childhood infections 


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Copyright information

© Humana Press Inc 1994

Authors and Affiliations

  • L. La Grenade
    • 1
  1. 1.Department of Medicine-Dermatology UnitUniversity of the West IndiesMonaJamaica

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