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Gastroenterologia Japonica

, Volume 25, Issue 3, pp 314–319 | Cite as

Cysteamine-induced duodenal ulcer and the hepatoduodenal branch of the vagus nerve

  • Kimitoshi Kato
  • Tomoaki Watanabe
  • Masahiko Itoh
  • Shuntaro Yoshida
  • Naohisa Hoshino
  • Kazuro Itoh
  • Fumiaki Sugimura
  • Ariyoshi Iwasaki
  • Yutaka Matsuo
  • Hiroko Sawai
  • Shigeyuki Imai
  • Susumu Oshiba
  • Atsuko Seki
Alimentary Tract

Summary

We investigated the role of the autonomic nervous system in gastric acid secretion, somatostatin concentration and PAS-positive mucus production in Brunner’s glands in cysteamine-induced duodenal ulcer. Vagotomized rats were used. No ulcers occurred in the groups with vagotomies of the hepatoduodenal, truncal or gastric branches after cysteamine administration. However, in the hepatoduodenal branch vagotomized group, there was an increases in gastric acid secretion after cysteamine administration. A similar increase was observed in the control group, but the decreases in somatostatin concentration and PAS-positive mucus seen in the control group were not found in the hepatoduodenal vagotomized group. These results suggest that the hepatoduodenal branch of the vagus nerve might play an important role in the ulcerogenic process of cysteamine-induced duodenal ulcer.

Key words

Brunner’s glands cysteamine-induced duodenal ulcer gastric acid secretion somatostatin hepatoduodenal branch of the vagus nerve 

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Copyright information

© The Japanese Society of Gastroenterology 1990

Authors and Affiliations

  • Kimitoshi Kato
    • 1
  • Tomoaki Watanabe
    • 1
  • Masahiko Itoh
    • 1
  • Shuntaro Yoshida
    • 1
  • Naohisa Hoshino
    • 1
  • Kazuro Itoh
    • 1
  • Fumiaki Sugimura
    • 1
  • Ariyoshi Iwasaki
    • 1
  • Yutaka Matsuo
    • 1
  • Hiroko Sawai
    • 2
  • Shigeyuki Imai
    • 2
  • Susumu Oshiba
    • 2
  • Atsuko Seki
    • 3
  1. 1.The Third Department of Internal MedicineNihon University School of MedicineTokyoJapan
  2. 2.Second Department of PhysiologyNihon University School of MedicineTokyoJapan
  3. 3.Third Department of Internal MedicineUniversity of Tokyo Faculty of MedicineTokyoJapan

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