Summary
Class II antigens in involved colonic epithelia of ulcerative colitis (UC), Crohn’s disease (CD), colorectal cancer, and epithelia of normal small intestine were investigated using an immunoperoxidase method. Ten normal colonic mucosa served as normal controls. Ten specimens were studied for each group. Normal colonie epithelia did not express class II antigens. In colonie diseases; (1) with regard to the frequency and extent of class II antigens on epithelia, HLA-DR antigens were the most highly and greatly expressed, followed by HLA-DP and then HLA-DQ antigens. (2) The extent of HLA-DR and -DP, but not HLA-DQ, expression on epithelia of UC and colorectal cancer seemed to be positively correlated with the degree of mononuclear cell infiltration in the lesion. (3) The extent of class II antigen expression on colonie epithelia in CD was not related to the degree of mononuclear cell infiltration in the lesion. (4) The extent of HLA-DR and -DP expression on epithelia of colorectal cancer seemed to be positively correlated with increasing undifferentiation. In the normal small intestine, where HLA-DR antigens were physiologically expressed on epithelia, HLA-DQ antigens were not expressed. The heterogeneity among colonie diseases, and between the physiological and pathological status, may reflect differences in immunoregulation.
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This work was partly supported by a grant from the Research Committee for Intractable Intestinal Diseases (Member; Osamu Masamune), Ministry of Health and Welfare, Japan.
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Horie, Y., Chiba, M., Iizuka, M. et al. Class II (HLA-DR, -DP, and -DQ) antigens on intestinal epithelia in ulcerative colitis, Crohn’s disease, colorectal cancer and normal small intestine. Gastroenterol Jpn 25, 575–584 (1990). https://doi.org/10.1007/BF02779357
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DOI: https://doi.org/10.1007/BF02779357