Gastroenterologia Japonica

, Volume 25, Issue 5, pp 575–584 | Cite as

Class II (HLA-DR, -DP, and -DQ) antigens on intestinal epithelia in ulcerative colitis, Crohn’s disease, colorectal cancer and normal small intestine

  • Yasuo Horie
  • Mitsuro Chiba
  • Masahiro Iizuka
  • Osamu Masamune
Alimentary Tract


Class II antigens in involved colonic epithelia of ulcerative colitis (UC), Crohn’s disease (CD), colorectal cancer, and epithelia of normal small intestine were investigated using an immunoperoxidase method. Ten normal colonic mucosa served as normal controls. Ten specimens were studied for each group. Normal colonie epithelia did not express class II antigens. In colonie diseases; (1) with regard to the frequency and extent of class II antigens on epithelia, HLA-DR antigens were the most highly and greatly expressed, followed by HLA-DP and then HLA-DQ antigens. (2) The extent of HLA-DR and -DP, but not HLA-DQ, expression on epithelia of UC and colorectal cancer seemed to be positively correlated with the degree of mononuclear cell infiltration in the lesion. (3) The extent of class II antigen expression on colonie epithelia in CD was not related to the degree of mononuclear cell infiltration in the lesion. (4) The extent of HLA-DR and -DP expression on epithelia of colorectal cancer seemed to be positively correlated with increasing undifferentiation. In the normal small intestine, where HLA-DR antigens were physiologically expressed on epithelia, HLA-DQ antigens were not expressed. The heterogeneity among colonie diseases, and between the physiological and pathological status, may reflect differences in immunoregulation.

Key words

class II (HLA-DR, -DP, and -DQ) antigens Crohn’s disease colorectal cancer small intestine ulcerative colitis 


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Copyright information

© The Japanese Society of Gastroenterology 1990

Authors and Affiliations

  • Yasuo Horie
    • 1
  • Mitsuro Chiba
    • 1
  • Masahiro Iizuka
    • 1
  • Osamu Masamune
    • 1
  1. 1.First Department of Internal MedicineAkita University School of MedicineAkitaJapan

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