Gastroenterologia Japonica

, Volume 25, Issue 6, pp 762–767 | Cite as

A case of gallbladder cancer producing granulocyte-colony-stimulating factor

  • Takehiko Takeda
  • Akihiro Ichiyanagi
  • Kaoru Sano
  • Jun Yoshida
  • Yutaka Tsutsumi
  • Toru Miyaji
Case Reports


A patient with pleomorphic giant cell carcinoma of the gallbladder also had mild neutrophilia, and this tumor was found to be human granulocyte colony-stimulating factor (G-CSF)-positive on immunohistochemical staining. CSF activity in urine and serum was not examined, but leukocytosis disappeared immediately after cholecystectomy. These findings suggest that this was a G-CSF-producing tumor.

Key words

colony-stimulating factor gallbladder cancer giant cell carcinoma 


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Copyright information

© The Japanese Society of Gastroenterology 1990

Authors and Affiliations

  • Takehiko Takeda
    • 1
  • Akihiro Ichiyanagi
    • 1
  • Kaoru Sano
    • 1
  • Jun Yoshida
    • 2
  • Yutaka Tsutsumi
    • 3
  • Toru Miyaji
    • 4
  1. 1.Department of Internal MedicineSano HospitalKobeJapan
  2. 2.Department of SurgerySano HospitalKobeJapan
  3. 3.Department of PathologyTokai University School of MedicineIseharaJapan
  4. 4.Japanese Institute of PathologyOsakaJapan

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