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Gastroenterologia Japonica

, Volume 25, Issue 6, pp 739–745 | Cite as

Adenosquamous carcinoma of the stomach presenting “giant gastric folds”

  • Keiichi Kawabe
  • Yasuni Nakanuma
  • Tadashi Terada
  • Yasutaka Nakamura
Case Reports
  • 14 Downloads

Summary

We report a case of adenosquamous carcinoma of the stomach. Grossly, the tumor showed “giant gastric folds” involving the fornix and body, and histologically was composed of adenocarcinoma and squamous cell carcinoma components. Both components diffusely proliferated and infiltrated in the gastric wall, mainly in the mucosa and submucosa, where prominent inflammatory changes such as desmoplasia and edema were observed. There were many intermingled foci of both components, and direct transitions between them were frequently observed. Immunohistochemically, adenocarcinoma cells were positive for secretory component and carcinoembryonic antigen and negative for involucrin, while the squamous cell carcinoma component was positive for involucrin and negative for carcinoembryonic antigen. It was suggested in this case that squamous metaplasia might have arisen multifocally in a preexisting adenocarcinoma and that diffuse proliferation and infiltration of carcinoma cells with prominent inflammatory changes in the submucosa might be responsible for the formation of “giant gastric folds”.

Key words

adenosquamous carcinoma gastric carcinoma giant gastric folds metaplasia 

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References

  1. 1.
    Oota K, Sobin LH: Histological typing of gastric and oesophageal tumours. International histological classification of tumours. No.18. World Health Organization, Geneva. 1977Google Scholar
  2. 2.
    Mori M, Iwashita A, Enjoji M: Adenosquamous carcinoma of the stomach. A clinicopathologic analysis of 28 cases. Cancer 1986;57:333–339PubMedCrossRefGoogle Scholar
  3. 3.
    Mori M, Iwashita A, Enjoji M: Squamous cell carcinoma of the stomach: report of three cases. Am J Gastroenterol 1986;81: 339–342PubMedGoogle Scholar
  4. 4.
    Ming SC: Tumours of the esophagus and stomach. In: Atlas of Tumour Pathology, Series 2, Fascicle 7, Armed Forces Institute of Pathology, Washington, DC. 1973;178–206Google Scholar
  5. 5.
    Hosi K, Hanyu H, Takeshita K, et al: Specific type of gastric cancer — Report of The 40th Japanese Gastric Cancer Study Group —. Jpn J Cancer Chemotherapy 1983:18:2112–2124 (in Japanese)Google Scholar
  6. 6.
    Yamagiwa Y, Yoshimura H, Tomiyama H, et al: Squamous change in patients with gastric carcinoma. Jap J Cancer Clin 1983:29:1721–1726 (in Japanese)Google Scholar
  7. 7.
    Johzaki H, Maruyama H, Maekawa T, et al: A case of squamous cell carcinoma with an grading of IIa + IIc, an early gastric cancer type. Jap J Cancer Clin 1988:34:1025–1030 (in Japanese)Google Scholar
  8. 8.
    Kumagai K, Yara A, Takizawa N, et al: A study on six cases of adenosquamous carcinoma of the stomach. Jap J Gastroent Surg 1980:13:886–890 (in Japanese)Google Scholar
  9. 9.
    Cook CB, Klickstein GD: Adenoacanthoma of the colon. Arch Path 1958:681–687Google Scholar
  10. 10.
    Namatame K, Ookubo M, Suzuki K, et al: A clinicopathological study on five cases adenosquamous carcinoma of the stomach. Jap J Cancer Clin 1986:32:170–175 (in Japanese)Google Scholar
  11. 11.
    Murakuni H, Kudo M, Wada T, et al: A case of primary adenosquamous carcinoma of the stomach and a clinicopathogic consideration of 135 cases reported in the Japanese literature. Gekashinryo 1988;30:543–546 (in Japanese).Google Scholar
  12. 12.
    Miyamoto T, Higashi H, Kuroda G, et al: A case of gastric adenosquamous carcinoma and a review of 114 cases in the literature. Geka 1983;44:262–268 (in Japanese)Google Scholar
  13. 13.
    Yamagiwa H. Adenosquamous cell carcinoma of gastrointestinal tract: I. Stomach. Rinshobyori 1985;33:674–678 (in Japanese)Google Scholar
  14. 14.
    Hsu SM, Raine L, Fanger H: Use of avidin-biootin-peroxidase complex (ABC) in immunoperoxidae techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577–580PubMedGoogle Scholar
  15. 15.
    Henderson DW, Papadimitriou JM: Ultrastructural appearances of tumours. A diagnostic atlas. Churchill Livingstone, Edinburg, London, Melbourne and New York. 1982Google Scholar
  16. 16.
    Watanabe K. Immunohistochemistry. Byori to Rinsho, Bunkodo Co., Tokyo. 1988 (in Japanese)Google Scholar
  17. 17.
    Fujitomi Y, Uchida Y, Shibata O, et al: A case of adenosquamous carcinoma of the stomach showing Borrmann 4 type and elevated serum CEA. Jpn J Gastroenterol 1983;80:1327–1330 (in Japanese)Google Scholar
  18. 18.
    Watanabe Y, Nakamura N, Iwasaki A, et al: Early gastric adenoacanthoma of superficial spreading type diagnosed by gastroscopy. Stomach and Intestine 1976:11:347–352 (in Japanese)Google Scholar
  19. 19.
    Kuwabara N, Watanabe S, Fukuda Y, et al: Gastric carcinoma of superficial spreading type with partial adenoacanthoma. Stomach and Intestine 1975:10:253–257 (in Japanese)Google Scholar
  20. 20.
    Schindler R: Gastric carcinoma and gastritis with reference to coexistence of carcinoma and chronic gastritis. Am J Dig Dis 10:607–624, 1965PubMedCrossRefGoogle Scholar
  21. 21.
    Wood DA: Adenoacanthoma of the pyloric end of the stomach. Arch Pathol 1943;36:177–189Google Scholar

Copyright information

© The Japanese Society of Gastroenterology 1990

Authors and Affiliations

  • Keiichi Kawabe
    • 1
  • Yasuni Nakanuma
    • 1
  • Tadashi Terada
    • 1
  • Yasutaka Nakamura
    • 2
  1. 1.Second Department of PathologyKanazawa University School of MedicineKanazawaJapan
  2. 2.Department of SurgeryNakamura HospitalTakefuJapan

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