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Gastroenterologia Japonica

, Volume 19, Issue 3, pp 221–226 | Cite as

Effect of caerulein administration on portal plasma somatostatin in dogs

  • Junji Kasanuki
  • Shigeru Fujimoto
  • Hideichi Marino
  • Azuma Kanatsuka
  • Terue Imaizumi
  • Hideaki Koseki
  • Ryoichi Kaneko
  • Yoshitaka Tokumasa
  • Sho Yoshida
Original Article
  • 6 Downloads

Summary

The effect of administration of synthetic caerulein on canine plasma somatostatin concentration in the portal vein was investigated using specific radioimmunoassay of acid-acetone extracted plasma. Gel chromatography revealed that the main component of the plasma somatostatin in the portal vein was identical with somatostatin-14. After administration of caerulein (5ng/kg), the somatostatin level increased significantly while the gastrin level remained unchanged. These results suggested that caerulein affects D cell function but not gastrin secretion.

Key Words

Plasma somatostatin Caerulein Radioimmunoassay 

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Copyright information

© The Japanese Society of Gastroenterology 1984

Authors and Affiliations

  • Junji Kasanuki
    • 1
  • Shigeru Fujimoto
    • 1
    • 2
  • Hideichi Marino
    • 1
  • Azuma Kanatsuka
    • 1
  • Terue Imaizumi
    • 1
  • Hideaki Koseki
    • 1
  • Ryoichi Kaneko
    • 1
  • Yoshitaka Tokumasa
    • 1
  • Sho Yoshida
    • 1
  1. 1.2nd Department of Internal MedicineChiba University School of MedicineChiba CityJapan
  2. 2.First Department of SurgeryChiba University School of MedicineChiba

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