Gastroenterologia Japonica

, Volume 19, Issue 4, pp 351–362 | Cite as

Abnormal intestinal flora: Metabolic and clinical consequences

  • Soad Tabaqchali
Proceeding of the Small Intestine Group in the Japanese Society of Gastroenterology Guest Lecture


Bile Acid Bile Salt Cholic Acid Bacterial Overgrowth Conjugate Bile Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Gorbach SL, Plant AG, Nahas L, Weinstein L: Studies of intestinal microflora. II. Micro-organisms of the small intestine and their relations to oral and faecal flora. Gastroenterology 53: 856, 1967PubMedGoogle Scholar
  2. 2).
    Drasar BS, Shiner M, McLeod CM: Studies on the intestinal flora. 1. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 56: 71–79, 1969PubMedGoogle Scholar
  3. 3).
    Gorbach SL, Tabaqchali S: Bacteria, bile and the small intestine. GUT 10: 963, 1969PubMedCrossRefGoogle Scholar
  4. 4).
    Tabaqchali S: The pathophysiological role of small intestinal bacterial flora. Scandinavian J Gastroenterology Suppl 6: 139, 1970Google Scholar
  5. 5).
    Midvedt T, Norman A: Bile acid transformations by microbial strains belonging to genera found in intestinal contents. Acta Pathologica et Microbiolgica Scandinvia 71: 629, 1967Google Scholar
  6. 6).
    Hill MJ, Drasar BS: Degradation of bile salts by human intestinal bacteria. GUT 9: 22, 1968PubMedCrossRefGoogle Scholar
  7. 7).
    Aries V, Hill MJ: The formation of unsaturated bile acids by intestinal bacteria. Biochemica Biophysica Acta 119: 37, 1970Google Scholar
  8. 8).
    Kim YS, Spritz N, Blum M, Terz J, Sherlock P: The role of the altered bile acid metabolism in steatorrhoea of experimental blind loop. J Clin Investigation 45: 959, 1966Google Scholar
  9. 9).
    Tabaqchali S, Hatziaonnou J, Booth CC: Bile salt deconjugation and steatorrhoea in patients with the stagnant loop syndrome. Lancet 2: 12, 1968PubMedCrossRefGoogle Scholar
  10. 10).
    Mekhjan HS, Phillips SF, Hofmann AF: Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Investigation 50: 1569, 1971Google Scholar
  11. 11).
    Gracey M: Intestinal absorption in the “contaminated small bowel syndrome”. GUT 12: 403–410, 1971PubMedCrossRefGoogle Scholar
  12. 12).
    Fromm H, Hofmann AF: Breath test for altered bile acid metabolism. Lancet2: 621–625, 1971PubMedGoogle Scholar
  13. 13).
    Lewis B, Panveliwalla D, Tabaqchali S, Wootton IDP: Serum bile acids in the stagnant loop syndrome. Lancet 1: 219, 1969PubMedCrossRefGoogle Scholar
  14. 14).
    Donaldson RM Jr: Small bowel bacterial overgrowth. Adv Intern Med 16: 191–212, 1970PubMedGoogle Scholar
  15. 15).
    Gianella RA, Broitman SA, Zamcheck N: Vitamin B12 uptake by intestinal micro-organisms; mechanisms and relevance to syndromes of bacterial overgrowth. J Clin Investigation 50: 1100–1107, 1971Google Scholar
  16. 16).
    Schjonsby H, Drasar BS, Tabaqchali S, Booth CC: Uptake of vitamin B12 by intestinal bacteria in the stagnent loop syndrome. Scand J Gastroent 8: 41–47, 1973PubMedGoogle Scholar
  17. 17).
    Hoffbrand AV, Tabaqchali S, Booth CC, Mollin DL: Small intestinal bacterial flora and folate status in gastrointestinal disease. GUT 12: 27, 1971PubMedCrossRefGoogle Scholar
  18. 18).
    Miller B, Mitchison R, Tabaqchali S, Neale G: The effects of excess bacterial proliferation on protein metabolism in rats with self-filling jejunal sacs. European J of Clin Investigation 2: 23, 1971CrossRefGoogle Scholar
  19. 19).
    Neale G, Gompertz D, Schjonsby H, Tabaqchali S, Booth CC: The metabolic and nutritional consequences of bacterial overgrowth in the small intestine. Am J Clin Nutrition 25: 1409, 1967Google Scholar
  20. 20).
    Neale G, Antcliffe AC, Welbourne RG, Mollin DL, Booth CC: Protein malnutrition after partial gastrectomy. Quarterly J of Med 25: 1409, 1967Google Scholar
  21. 21).
    King CE, Toskes PP: Small intestinal bacterial overgrowth. Gastroenterology 76: 1035–1055, 1979PubMedGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1984

Authors and Affiliations

  • Soad Tabaqchali
    • 1
  1. 1.Department of Medical MicrobiologySt Bartholomew’s HospitalLondon

Personalised recommendations