Effects of low-molecular-weight aluminum complexes on brain tissue calcium homeostasis
- 41 Downloads
The in vitro effects of low-molecular-weight aluminum complexes (citrate, lactate, and ATP complex) on the Ca2+ uptake and aluminum-induced lipid peroxidation of brain tissue show that the modification of the calcium homeostasis is determined by the nature of the ligand and that there is no correlation between the aluminum-induced lipid peroxidation and the Ca2+ uptake. The same characteristics have been shown by a similar study performed with Ehrlich carcinoma cells. The electrophoretic analyses of the aluminum lactate-albumin and aluminum lactate-ATP interactions indicate an aluminum transfer from the lactate to the albumin and ATP ligands. The increased Ca2+ uptake when ATP is present in the incubation medium with aluminum citrate and aluminum lactate corroborates the suggested mediator role of ATP in cellular calcium homeostasis modification induced by iron.
Index EntriesBrain calcium homeostasis low-molecular-weight aluminum complexes
Unable to display preview. Download preview PDF.
- 8.L. J. Anghileri, P. Maincent, A. Cordova Martinez, and J. Escanero, Effects of albumin and adenosine phosphates on iron transfer from ferric lactate,Biol. Trace Element Res. 40, 83–88 (1994).Google Scholar
- 12.M. A. Burnatowska-Hledin and G. H. Mayor, The effects of aluminum loading on selected tissue calcium and magnesium concentration in rats,Biol. Trace Element Res. 6, 531–535 (1984).Google Scholar
- 13.P. R. S. Kodavanti, W. R. Mundy, H. A. Tilson and G. J. Harry, Effects of selected neuroactive compounds on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells,Toxicologist 12, 128–132 (1992).Google Scholar
- 17.L. J. Anghileri, M. Heidbreder, G. Weiler, and R. Dermietzel, Liver tumors induced by 4-dimethylaminoazobenzene. Experimental basis for a chemical carcinogenesis concept,Arch. Geschwultsforsch 46, 639–646 (1976).Google Scholar
- 19.L. J. Anghileri, D. Stavrou and W. Weidenbach, Phospholipids and calcification in human intracranial tumors,Arch. Geschwultsforsch. 47, 330–334 (1977).Google Scholar
- 22.M. Deleers, Cationic atmosphere and cation competition binding at negative charged membranes. Pathological implications of aluminum,Res. Commun. Chem. Pathol. Pharmacol. 49, 277–294 (1981).Google Scholar
- 23.P. Nicotera and S. Orrenius, Calcium ions in necrotic and apoptotic cell death, inNeurodegeneration and Neuroprotection in Parkinson’s Diease, C. W. Olanov, P. Jenner, and M. Youdim, eds, Academic, London, p. 155 (1996).Google Scholar