Abstract
The in vitro effects of low-molecular-weight aluminum complexes (citrate, lactate, and ATP complex) on the Ca2+ uptake and aluminum-induced lipid peroxidation of brain tissue show that the modification of the calcium homeostasis is determined by the nature of the ligand and that there is no correlation between the aluminum-induced lipid peroxidation and the Ca2+ uptake. The same characteristics have been shown by a similar study performed with Ehrlich carcinoma cells. The electrophoretic analyses of the aluminum lactate-albumin and aluminum lactate-ATP interactions indicate an aluminum transfer from the lactate to the albumin and ATP ligands. The increased Ca2+ uptake when ATP is present in the incubation medium with aluminum citrate and aluminum lactate corroborates the suggested mediator role of ATP in cellular calcium homeostasis modification induced by iron.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. J. Anghileri, Effects of Fe3+-tumor cell interaction on Ca2+-uptake by Ehrlich ascites tumor cells,Cell Calcium 12, 371–374 (1991).
L. J. Anghileri, Ehrlich tumor cells: Ca2+-uptake modification by aluminum lactate,Cell Calcium 13, 277–279 (1992).
L. J. Anghileri, P. Maincent, A. Cordova Martinez, and P. Thouvenot, The role of ATP as a mediator in the action of iron complexes on cellular calcium homeostasis.Biol. Trace Element Res. 46, 103–111 (1994).
L. J. Anghileri, P. Thouvenot, and A. Bertrand, Effects of iron complexes on brain calcium homeostasis,Ann. Clin. Lab. Sci. 27, 210–215 (1997).
J. M. C. Gutteridge, Ferrous ion-EDTA-stimulated phospholipid peroxidation,Biochem. J. 224, 697–701 (1984).
A. D. Horton and P. F. Thomason, Ion exchange—spectrophotometric determination of aluminum,Anal. Chem. 28, 1326–1329 (1956).
J. E. Gorman and F. M. Clydesdale, Thermodynamic and kinetic stability constants of selected carboxylic acids and iron,J. Food Sci. 49, 500–504 (1984).
L. J. Anghileri, P. Maincent, A. Cordova Martinez, and J. Escanero, Effects of albumin and adenosine phosphates on iron transfer from ferric lactate,Biol. Trace Element Res. 40, 83–88 (1994).
M. Favarato, P. Zatta, M. Perazzolo, L. Fontana, and M. Nicolini, Aluminum influence on the permeability of blood-brain barrier to (14C)sucrose in rats.Brain Res. 569, 330–335 (1992).
R. A. Yokel, V. Lidums, P. J. McNamara, and V. Ungerstedt, Aluminum distribution into brain and liver of rats and rabbits following intravenous aluminum lactate or citrate: a microdialysis study,Toxicol. Appl. Pharmacol. 107, 153–163 (1991).
S. K. Jonas and P. A. Riley, The effect of ligands on the uptake of iron by cells in culture.Cell Biochem. Funct. 9, 245–253 (1991).
M. A. Burnatowska-Hledin and G. H. Mayor, The effects of aluminum loading on selected tissue calcium and magnesium concentration in rats,Biol. Trace Element Res. 6, 531–535 (1984).
P. R. S. Kodavanti, W. R. Mundy, H. A. Tilson and G. J. Harry, Effects of selected neuroactive compounds on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells,Toxicologist 12, 128–132 (1992).
L. J. Anghileri, Effects of complexed iron and aluminum on brain calcium,Neurotoxicology 13, 475–478 (1992).
L. J. Anghileri, P. Maincent, and P. Thouvenot, Modification of in vivo Ca2+-uptake by parenterally administered aluminum complexes,In Vivo 8, 237–240 (1994).
R. N. MacBurney and I. R. Neering, Neuronal calcium homeostasis,Trends Neuro-Sci. 10, 164–169 (1987).
L. J. Anghileri, M. Heidbreder, G. Weiler, and R. Dermietzel, Liver tumors induced by 4-dimethylaminoazobenzene. Experimental basis for a chemical carcinogenesis concept,Arch. Geschwultsforsch 46, 639–646 (1976).
L. J. Anghileri, M. Heidbreder, G. Weiler, and R. Dermietzel, Hepatocarcinogenesis by thioacetamide: correlations of histological and biochemical changes, and possible role of cell injury,Exp. Cell Biol. 45, 34–47 (1977).
L. J. Anghileri, D. Stavrou and W. Weidenbach, Phospholipids and calcification in human intracranial tumors,Arch. Geschwultsforsch. 47, 330–334 (1977).
M. Yasui, T. Kihira, and K. Ota, Calcium, magnesium and aluminum concentrations in Parkinson’s disease,Neurotoxicology 13, 593–600 (1992).
E. Carafoli, Intracellular calcium homeostasis,Annu. Rev. Biochem. 56, 395–433 (1987).
M. Deleers, Cationic atmosphere and cation competition binding at negative charged membranes. Pathological implications of aluminum,Res. Commun. Chem. Pathol. Pharmacol. 49, 277–294 (1981).
P. Nicotera and S. Orrenius, Calcium ions in necrotic and apoptotic cell death, inNeurodegeneration and Neuroprotection in Parkinson’s Diease, C. W. Olanov, P. Jenner, and M. Youdim, eds, Academic, London, p. 155 (1996).
L. J. Anghileri, P. Maincent, and P. Thouvenot, Role of lipid peroxidation in iron-induced calcium overload,Biol. Trace Element Res. 52, 163–169 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Anghileri, L.J., Thouvenot, P. & Bertrand, A. Effects of low-molecular-weight aluminum complexes on brain tissue calcium homeostasis. Biol Trace Elem Res 63, 205–212 (1998). https://doi.org/10.1007/BF02778938
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02778938