Biological Trace Element Research

, Volume 63, Issue 2, pp 139–147 | Cite as

Effect of oral aluminum and aluminum citrate on blood level and short-term tissue distribution of aluminum in the rat

  • Zeyuan Deng
  • Charles Coudray
  • Laurent Gouzoux
  • Andrzej Mazur
  • Yves Rayssiguier
  • Denise Pépin


Aluminum (Al) absorption seems to be very low, but many factors can enhance it in animals and humans. In the present study, we investigated the acute effect of Na citrate on Al absorption by monitoring Al levels in blood and several tissues. For this purpose, 18 Wistar male rats were divided into 3 groups: control, Al, and Al + Na citrate. After a 14-h fasting period, animals were dosed orally with deionized water, or 2 mmol Al chloride, or 2 mmol Al chloride plus 2 mmol Na citrate. Blood samples were taken before and 1, 2, 4, and 6 h after the gavage. Al concentrations in blood, liver, tibia, kidney, and intestinal wall were determined by ICP-OES. In the Al and Al + citrate groups, Al blood concentrations peaked at 1 h and 2 h with higher levels in the Al + citrate group. Al gavage resulted in an increase in Al level in intestinal wall, but not in the other investigated tissues. Simultaneous gavage of citrate with Al significantly increased its tissue levels in tibia, kidney, and in intestinal wall. Our data show clearly that Al as chloride can be absorbed, but not well retained by the organism tissues. Furthermore, the model used in the present study is appropriate for acute studies to investigate the effect of various compounds on Al absorption in the rat.

Index Entries

Aluminum citrate absorption status rat 


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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Zeyuan Deng
    • 1
  • Charles Coudray
    • 2
  • Laurent Gouzoux
    • 3
  • Andrzej Mazur
    • 2
  • Yves Rayssiguier
    • 2
  • Denise Pépin
    • 3
  1. 1.Food Nutrition Laboratory, Food Science DepartmentNanchang UniversityNanchangChina
  2. 2.Centre de Recherche en Nutrition Humaine d’Auvergne, Unité des Maladies Métaboliques et MicronutrimentsCentre d’INRA Clermont-Ferrand/TheixSaint Genès ChampanelleFrance
  3. 3.Laboratoire de Contrôle des EauxInstitut Louise Blanquet, Faculté Médecine et PharmacieClermont-FerrandFrance

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