Solitary pedunculated polypoid gastric gland heterotopia

  • Wei Hou
  • Ken Haruma
  • Koji Sumii
  • Masaharu Yoshihara
  • Toshitaka Tsuda
  • Takehiro Shimamoto
  • Goro Kajiyama
  • Hisao Ito
Case Reports


A solitary pedunculated gastric polyp in the gastric fundus was removed from an asymptomatic 36-year-old woman with normal gastric acid secretion and a normal serum gastrin level. This lesion exhibited distinctive histological features including prominent proliferation of pseudopyloric glands, fundic glands, foveolar epithelium and a fibromuscular stroma. Moreover, its surface was entirely covered by a layer of normal gastric epithelium. Biopsies of the background mucosa taken from the gastric fundus revealed only mild superficial gastritis. A gastric gland heterotopia was diagnosed because of its unique morphology.

Key words

Gastric gland heterotopia Morphology Gastric acid Serum gastrin 


  1. 1.
    Ming SG, Goldman H. Gastric polyps; A histogenetic classification and its relation to carcinoma Cancer 1965;18:721–726.PubMedCrossRefGoogle Scholar
  2. 2.
    Ming SG. The classification and significance of gastric polyps. In: Yardley JH, Morson BC, Abell MR, eds. International academy of pathology monography series: The gastrointestinal tract. Baltimore: Waverly Press, Inc., 1977;149–175.Google Scholar
  3. 3.
    Tomasulo J. Gastric polyps; histologic types and their relationship to gastric carcinoma. Cancer 1971;27:1346–1355.PubMedCrossRefGoogle Scholar
  4. 4.
    Elster K. Histologic classification of gastric polyps. Curr Top Pathol 1976;63:77–93.PubMedGoogle Scholar
  5. 5.
    Snover DC. Benign epithelial polyps of the stomach. Pathol Annu 1985;21:303–329.Google Scholar
  6. 6.
    Burdic D, Prior JT, Scanlon GT. Peutz-Jeghers’ syndrome; A clinicopathological study of a large family with a 10-year follow-up. Cancer 1963;16:854–867.CrossRefGoogle Scholar
  7. 7.
    Dawson I. Hamartomas in the alimentary tract. Gut 1969;10:691–694.PubMedCrossRefGoogle Scholar
  8. 8.
    Rintala A. The histological appearance of gastrointestinal polyps in the Peutz-Jeghers’ syndrome. Acta Chir Scandinav 1959;117:366–373.Google Scholar
  9. 9.
    Carfagna G, Pilato FP, Bordi C. Solitary polypoid hamartoma of the oxyntic mucosa of the stomach. Pathol Res Pract 1981;182: 326–330.Google Scholar
  10. 10.
    Hanada M, Takami M, Kazuya H, et al. Hyperplastic fundic gland polyp of the stomach. Acta Pathol Jpn 1983;33:1269–1277.PubMedGoogle Scholar
  11. 11.
    Tatsuta M, Saegusa T, Okuda S. Studies on gastritis in the upper portion of stomach by endoscopic Congo Red test. Endoscopy 1973;5:61–69.Google Scholar
  12. 12.
    Ito H, Hata J, Yokozaki H, et al. Tubular adenoma of the human stomach—an immunohistochemical analysis of gut hormones, serotonin, carcinoembryonic antigen, secretory component, and lysozyme. Cancer 1986;58:2264–2272.PubMedCrossRefGoogle Scholar
  13. 13.
    Davis GR. Gastric polyps. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal disease, 4th ed. Philadelphia: WB Saunders Co., 1989;763–764.Google Scholar
  14. 14.
    Nelson RS, Lanza FL. Hyperplastic polyps. In: Berk JE, Haubrich WS, Kaiser MH, Roth JLA, Schaffner F, eds. Bockus, Gastroenterology, 4th ed. Philadelphia: WB Saunders Co., 1985;2:1255–1257.Google Scholar
  15. 15.
    Sakurada H, Ishima A, Arakawa H, et al. Comparative study on gastric secretory function between benign gastric polyp and elevated type of early stomach cancer with special reference to histological findings of gastric mucosa. Tohoku J Exp Med 1976; 118(suppl):39–43.PubMedCrossRefGoogle Scholar
  16. 16.
    Siurala M, Lehtola J, Ihamaki T. Atrophie gastritis and its sequelae. Scand J Gastroenterol 1974;9:441–446.PubMedGoogle Scholar
  17. 17.
    Elsborg L, Ardersen D, Gastrup-madsen P. Gastrocamera screening in pernicious anemia with special reference to the occurrence of gastric polyps and cancer. Scand J Gastroenterol 1973;8:5–8.PubMedGoogle Scholar
  18. 18.
    Haruma K, Sumii K, Kimura M, et al. Gastric mucosa in patients with foveolar hyperplastic polyps—with special reference to gastric acid secretion, serum gastrin level, and serum pepsinogen I level. Gastroenterological Endoscopy 1989;31:2051–2059 (in Japanese with English abstract).Google Scholar
  19. 19.
    Kuwano H, Takano H, Sugimachi K. Solitary Peutz-Jeghers’ type polyp of the stomach in the absence of Familial Polyposis Coli in a teenage boy. Endoscopy 1989;21:188–190.PubMedCrossRefGoogle Scholar
  20. 20.
    Horn RC, Payne WA, Fine F. The Peutz-Jeghers’ syndrome (gastrointestinal polyposis with mucocutaneous pigmentation): report of a case terminating with disseminated gastrointestinal cancer. Arch Pathol 1963;76:29–37.PubMedGoogle Scholar
  21. 21.
    Hara M, Tsutsumi Y, Watanabe K, et al. Solitary gastric polyps in the fundic gland area, A histochemical study. Acta Pathol Jpn 1985;35:835–840.Google Scholar
  22. 22.
    Watanabe H, Jass JR, Sobin LH. Gastric Gland Heterotopia. In: Watanabe H, Jass JR, Sobin LH in Collaboration with Pathologists in 8 Countries, eds. Histological Typing of Oesophageal and Gastric Tumours. New York: Springer-Verlag, 1990;35–36.Google Scholar

Copyright information

© The Japanese Society of Gastroenterology 1993

Authors and Affiliations

  • Wei Hou
    • 1
  • Ken Haruma
    • 1
  • Koji Sumii
    • 1
  • Masaharu Yoshihara
    • 1
  • Toshitaka Tsuda
    • 1
  • Takehiro Shimamoto
    • 1
  • Goro Kajiyama
    • 1
  • Hisao Ito
    • 2
  1. 1.The First Department of Internal MedicineHiroshima University School of MedicineHiroshimaJapan
  2. 2.First Department of PathologyHiroshima University School of MedicineHiroshimaJapan

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