Gastroenterologia Japonica

, Volume 25, Issue 2, pp 223–229 | Cite as

Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats

  • Masataka Okuno
  • Akio Noma
  • Yasutoshi Muto
  • Hisataka Moriwaki
  • Michimasa Kato
  • Osamu Tagaya
  • Yoshimi Nozaki
  • Yoshikazu Suzuki
Liver and Pancreas


A study was conducted to examine the inhibitory effect of acyclic retinoid (polyprenoic acid) on the development of hepatic fibrosis induced by CC14 in rats. Oral administration of the compound brought about a significant reduction in both serum and tissue levels of immunoreactive prolyl hydroxylase, a key enzyme of collagen formation. The result indicated that the rate of collagen synthesis in the liver was decreased which was consistent with histological findings. Acyclic retinoid also decreased both AST and ALT activities in serum, demonstrating the reduction in hepatic parenchymal damage. This cytoprotective effect on parenchymal cells may be related, at least in part, to inhibition of hepatic fibrosis. No significant side effects were observed, despite a long-term administration of the acyclic retinoid. The present findings suggest the potential scope of therapy of hepatic fibrosis by retinoid.

Key words

carbon tetrachloride hepatic fibrosis hydroxyproline prolyl hydroxylase retinoid 


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Copyright information

© The Japanese Society of Gastroenterology 1990

Authors and Affiliations

  • Masataka Okuno
    • 1
  • Akio Noma
    • 1
  • Yasutoshi Muto
    • 2
  • Hisataka Moriwaki
    • 2
  • Michimasa Kato
    • 2
  • Osamu Tagaya
    • 3
  • Yoshimi Nozaki
    • 3
  • Yoshikazu Suzuki
    • 3
  1. 1.Department of Laboratory MedicineGifu University School of MedicineGifu CityJapan
  2. 2.First Department of Internal MedicineGifu University School of MedicineGifu CityJapan
  3. 3.Department of Drug Safety ResearchEisai Co., Ltd.Japan

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