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Gastroenterologia Japonica

, Volume 22, Issue 5, pp 588–590 | Cite as

Effect of lidamidine on transepithelial potential difference evoked by prostaglandin E2 in human jejunum

  • Hiroshi Masukawa
  • Masayuki Kaneko
  • Tsuneo Takahashi
  • Makoto Ishikawa
  • Yuichi Suzuki
Original Article
  • 12 Downloads

Summary

The effect of the infusion of lidamidine, an antidiarrheal drug, on the change in transepithelial potential difference (TPD) induced by the infusion of prostaglandin E2 (PGE2) was examined in perfused human jejunum in vivo. The increase in luminal negativity of TPD produced by 3 X 10-7 M PGE2 was significantly decreased from 2.8 ± 0.5 mV to 1.2 ± 0.5 mV by the superimposed infusion of 2 X 10-3 M lidamidine. This result may suggest that lidamidine has an inhibitory effect on intestinal Cl secretion which is stimulated by PGE2.

Key words

Cl secretion Human jejunum Lidamidine Potential difference Prostaglandin E2 

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References

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Copyright information

© The Japanese Society of Gastroenterobgy 1987

Authors and Affiliations

  • Hiroshi Masukawa
    • 1
  • Masayuki Kaneko
    • 1
  • Tsuneo Takahashi
    • 1
  • Makoto Ishikawa
    • 1
  • Yuichi Suzuki
    • 2
  1. 1.The Second Department of Internal MedicineYamagata University School of MedicineYamagataJapan
  2. 2.Department of PhysiologyYamagata University School of MedicineYamagataJapan

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