Advertisement

Gastroenterologia Japonica

, Volume 11, Issue 2, pp 116–122 | Cite as

Effect of premedication of Coenzyme Q10 on pancreozymin-induced pancreatic secretion in rats

  • Toshihiro Suga
Original Article
  • 13 Downloads

Summary

Effect of Coenzyme Q10 (CoQ10), an essential coenzyme in oxidative phosphorylation in the mitochondria, was studied in the rat’s pancreas. A dose of pancreozymin (0.2 u/100 g body wt) was injected into the femoral vein at 20 min intervals. The initial injection produced a definite increase in amylase output and the pancreatic juice flow. Subsequent injections, however, caused smaller responses than the preceding (tachyphylaxis). When CoQ10 (3 mg/100 g body wt) had been administrated 1 hour prior to the initial stimulation, both the amylase output and the rate of juice flow were significantly enhanced: the tachyphylaxis almost disappeared. Effect of CoQ10 was also observed in the isolated and perfused pancreas. CoQ10 produced slight increase in pancreozymin-induced amylase output, but the increase was not significant. The effect of CoQ10, to increase the pancreatic blood flow, seems to be involved in thein situ effect of CoQ10 in cooperation with the direct effect on pancreatic acinar cells.

Key Word

coenzyme Q10 pancreatic secretion dual effects of pancreozymin tachyphylaxis pancreatic blood flow 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Bauduin, H., Colin, M. and Dumont, J.E.: Biochem. Biophys. Acta. 174: 722, 1969.Google Scholar
  2. 2).
    Kanno, T.: J. Physiol (Lond.). 245: 599, 1975.Google Scholar
  3. 3).
    Morton, R.A.: Nature 182: 1964, 1958.Google Scholar
  4. 4).
    Lester, R.L. and Crane, F.I.: J. Biol. Chem. 234: 2169, 1959.Google Scholar
  5. 5).
    Folkers, K.: Internat. J. Vit. Res. 39: 334, 1969.Google Scholar
  6. 6).
    Green, D.E. and Tzagolon, A.: Arch. Biochem. Biophys. 116: 293, 1966.Google Scholar
  7. 7).
    Ruzicka, F.J. and Crane, F.L.: Biochim. Biophys. Acta 223: 71, 1970.Google Scholar
  8. 8).
    Kanno, T., Suga, T. and Yamamoto, M.: Japan. J. Physiol. 26: 101, 1976Google Scholar
  9. 9).
    Bernfeld, P.: Methods in Enzymology, Vol. 1, ed. S.P. Coloquick, N.O. Kaplan pp.149–-158. New York: Academic Press.Google Scholar
  10. 10).
    Crick, J., Haper, A.A. and Raper, H.S.: J. Physiol. (Lond.). 110: 367, 1950.Google Scholar
  11. 11).
    Heatley, N.G.: J. Endocrinsl. 42: 535, 1968.CrossRefGoogle Scholar
  12. 12).
    Dockray, G.J.: J. Physiol. (Lond.). 225: 679, 1972.Google Scholar
  13. 13).
    Yamamoto, N., Hatakeyama, H., Nishikawa, K. and Horio, T.: J. Biochem. 67: 587, 1970.PubMedGoogle Scholar
  14. 14).
    Yamamoto, H., Masuda, M., Nishino, H. and Muramo, T.: Japan. J. Pharmacol. 22: 707, 1972.Google Scholar
  15. 15).
    Mizutani, K. et al.: Clinical Physiology 2: 602, 1972.Google Scholar
  16. 16).
    Cahn, J., Herold, M.M., Kabacoff, O., Helbecque, C., Barre, N. and Tassart, O.: Revue Agressologie 2: 221, 1961.Google Scholar
  17. 17).
    Pascal, J.P., Vaysse, N., Boucard, J.P., Labal, J. Ribet, A.: Biol. et Gastro-ent. 4: 279, 1971.Google Scholar
  18. 18).
    Augier, O., Boucard, J.P., Pascal, J.P., Ribet, A. and Vaysse, N.: J. Physiol. (Lond.). 221: 55, 1972.Google Scholar
  19. 19).
    Tsuruoka, M. et al.: The effect of pancreatic blood flow on pancreatic exocrine secretion. Presentation at 17th meeting of Japanese society of gastroenterology, 2, Oct. 1975 in Nagasaki.Google Scholar
  20. 20).
    Wagner, A.F., Stopkie, R.J. and Folkers, K.: Arch. Biochem. Biochem. Biophys. 107: 184, 1964.Google Scholar
  21. 21).
    Smith, J.L., Scholler, J., Moore, H.W., Farley, T.M. and Folkers, K.: Arch. Biochem. Biophys. 116: 129, 1966.Google Scholar
  22. 22).
    Sövik, O., Strömme, J.H. and Folkers, K.: Acta Paediat. Scand. 60: 428, 1971.Google Scholar
  23. 23).
    Folkers, K., Nakamura, R., Littarru, G.P., Zellweger, H., Brunkhorst, J.B., Williams, C.W. Jr. and Langsten, J.H.: Proc. Nat. Acad. Sci. USA 71: 2098, 1974.PubMedCrossRefGoogle Scholar
  24. 24).
    Tsunemitsu, A. and Matsumura, T.: J. Dental Res. 46: 1382, 1968.Google Scholar
  25. 25).
    Honjo, K., Tsukamoto, Y., Nakamura, R., Tsunemitsu, A. and Matsumura, T.: Arch. Oral Biol. 11: 543, 1966.CrossRefGoogle Scholar
  26. 26).
    Page, Jr. A.C., Smith, M.C., Gale, P.H., Polin, D. and Folkers, K.: Biochem. Biophys. Res. Comm. 6: 141, 1961.Google Scholar
  27. 27).
    Hashiba, K. et al.: Shinzo 4: 1579, 1972. (in Japanese)Google Scholar
  28. 28).
    Igarashi, T., Nakajima, Y., Tanaka, M. and Ohtake, S.: J. Pharm. Exper. Therap. 189: 149, 1974.Google Scholar
  29. 29).
    Iwamoto, Y., Yamagami, T. and Folkers, K.: Bioch. Biophys. Res. Comm. 58: 743, 1974.Google Scholar

Copyright information

© The Japanese Society of Gastroenterology 1976

Authors and Affiliations

  • Toshihiro Suga
    • 1
  1. 1.Department of Physiology, Faculty of Veterinary MedicineHokkaido UniversitySapporoJapan

Personalised recommendations