Gastroenterologia Japonica

, Volume 11, Issue 2, pp 116–122 | Cite as

Effect of premedication of Coenzyme Q10 on pancreozymin-induced pancreatic secretion in rats

  • Toshihiro Suga
Original Article


Effect of Coenzyme Q10 (CoQ10), an essential coenzyme in oxidative phosphorylation in the mitochondria, was studied in the rat’s pancreas. A dose of pancreozymin (0.2 u/100 g body wt) was injected into the femoral vein at 20 min intervals. The initial injection produced a definite increase in amylase output and the pancreatic juice flow. Subsequent injections, however, caused smaller responses than the preceding (tachyphylaxis). When CoQ10 (3 mg/100 g body wt) had been administrated 1 hour prior to the initial stimulation, both the amylase output and the rate of juice flow were significantly enhanced: the tachyphylaxis almost disappeared. Effect of CoQ10 was also observed in the isolated and perfused pancreas. CoQ10 produced slight increase in pancreozymin-induced amylase output, but the increase was not significant. The effect of CoQ10, to increase the pancreatic blood flow, seems to be involved in thein situ effect of CoQ10 in cooperation with the direct effect on pancreatic acinar cells.

Key Word

coenzyme Q10 pancreatic secretion dual effects of pancreozymin tachyphylaxis pancreatic blood flow 


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Copyright information

© The Japanese Society of Gastroenterology 1976

Authors and Affiliations

  • Toshihiro Suga
    • 1
  1. 1.Department of Physiology, Faculty of Veterinary MedicineHokkaido UniversitySapporoJapan

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