Gastroenterologia Japonica

, Volume 20, Issue 2, pp 143–147 | Cite as

Improvement of endoscopic and histologic findings of aa-type gastrointestinal amyloidosis by treatment with dimethyl sulfoxide and prednisolone

  • Akira Takahashi
  • Junji Matsumoto
  • Shoji Nishimura
  • Noritoshi Tanida
  • Shigeaki Imura
  • Takashi Isobe
  • Takashi Shimoyama
Case Report


We report the successful treatment of gastrointestinal amyloidosis with dimethyl sulfoxide. A 37 yearold man with adult-onset Still’s disease suffered from diarrhea. Upper and lower gastrointestinal endoscopy revealed edematous mucosa, white patches, erosions and bleeding and amyloid deposits were demonstrated in biopsy specimens. After a period of 3 months dimethyl sulfoxide and prednisolone therapy, improvement in the endoscopic appearance of the gastrointestinal tract was observed. Amyloid deposits in biopsy specimens were reduced in the stomach and negative in the large intestine.

Key word

Amyloidosis Intestines Endoscopy Dimethyl sulfoxide Still’s diseasc 


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Copyright information

© The Japanese Society of Gastroenterologe 1985

Authors and Affiliations

  • Akira Takahashi
    • 4
  • Junji Matsumoto
  • Shoji Nishimura
  • Noritoshi Tanida
    • 1
  • Shigeaki Imura
    • 2
  • Takashi Isobe
    • 3
  • Takashi Shimoyama
    • 4
  1. 1.Department of MedicineKakogawa National HospitalKakogawashi, Hyogo
  2. 2.OrthopedicsKakogawa National HospitalKakogawashi, Hyogo
  3. 3.Third Division, Department of MedicineKobe University School of MedicineKobe 650
  4. 4.Department of Internal Medicine 4Hyogo College of MedicineNishinomiya, Hyogo

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