Thalassemic cardiopathy: Current concepts
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Transfusion-dependent patients with thalassemia major are at an extremely high risk of cardiomyopathy. Traditional methods of evaluating left ventricular performance in order to detect the subjects with subtle cardiac dysfunction, are not predictive because of various hemodynamic compensatory mechanisms. Considerable interest has been generated in newer criteria of detecting earliest evidence of cardiac dysfunction. Based upon these recent techniques, guidelines for modulating the therapy can be framed and serial non-invasive followup of these patients can be carried out. However, even optimal chelation therapy does not appear to prevent onset of cardiomyopathy.
Key wordsThalassemia major cardiomyopathy left ventricular performance covert left ventricular dysfunction
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