The Indian Journal of Pediatrics

, Volume 51, Issue 6, pp 637–641 | Cite as

Free fatty acids and triglycerides in normoglycemic low birth weight newborns in early neonatal period

  • P. K. Misra
  • D. K. Tiwari
  • B. Sharma
  • R. Kaul
Original Articles


Free fatty acids, triglycerides and blood sugar were estimated in 45 lowbirth weight which included 24 preterm and 21 small for gestational age term babies, in the cord blood, in the fasting state at 6±1 h of age, and after initiation of sugar water feeds at 24±2 h of age. Thirty six appropriate for gestational age, term newborns were taken as controls. None of the newborns were born to diabetic mothers or had hypoglycemia. Mean cord blood sugar levels in all the groups were similar ranging between 69.55 to 73.7 mg/dl. followed by a fall in all at 6±1 h and subsequent rise at 24±2h. levels were significantly lower in LBW newborns compared to controls. Means FFA levels were lowest in babies with agestation of 28–32 weeks (0.27 m Mol/L), being almost similar to controls (0.35 mMol/L) in preterm 33–36 weeks (0.32 mMol/L) and higher than controls in SGA (0.48 mMol/L). An inverse relationship with blood sugar level was seen in serial estimations. SGA neonates continued to show higher and preterm (28–32 weeks) lowest levels throughout the study period. Triglycerides in cord blood were 36.72 mg/dl, 38.33 mg/dl, 56.23 mg/dl and 40.11 mg per cent in preterm 28–32 weeks, 33–36 weeks, SGA term and controls respectively. Levels showed a steady rise during the study period.

Key words

Free fatty acids triglycerides blood sugar low birth weight newborns SGA newborns AGA term newborns normoglycemic 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cornblath M. Schwartz R:Disorders of carbohydrate metabolism in infancy. WB Saunders. Philadelphia and London. 1976, p 73Google Scholar
  2. 2.
    Lubchenco LO, Hansman C. Dressler M, Boy E Intrauterine growth as estimated from live born birth weight date at 24 to 42 wecks of gestation.Pediatrics 32: 794, 1963Google Scholar
  3. 3.
    Asatoor A, King EJ: Simplified colorimetric blood sugar method.Biochem J XLIV: 56, 1954Google Scholar
  4. 4.
    Mosinger F: Photoelectic adaptation of Dole’s Microdetermination of free fatty acids.J lipid Res 6: 157, 1965PubMedGoogle Scholar
  5. 5.
    Van Handel E, Zilversmit DB: Micromethod for direct determination of serum.TG J Lab Clin Med 50: 152, 1957Google Scholar
  6. 6.
    Jagannathan SN: The determination of plasma triglycerides.Canadian J Biochem 42: 566, 1964CrossRefGoogle Scholar
  7. 7.
    Lambert M, Neish AC: Rapid method for estimation of glycerides in fermentation solution.Canad J Res 28: 83, 1950Google Scholar
  8. 8.
    Pedersen LM, Wagner L, Klebe JG, Pedersen J: Aspects of carbohydrate metabolism in newborn infants of diabetic mothers.Acta Endocrinologica 71: 338, 1972PubMedGoogle Scholar
  9. 9.
    Creey RDG, Parkinson TJ: Blood glucose changes in the newborns in first 12 hours of life.Arch Dis Child 28: 134, 1953CrossRefGoogle Scholar
  10. 10.
    Konig S. Vest M, Stahl M: Interrelation of maternal and fetal glucose and free fatty acids—The role of insulin and glucagon.Eu J Pediatr 128: 187, 1978CrossRefGoogle Scholar
  11. 11.
    Norval MA: Blood sugar values in premature infants.J Pediat 36: 177, 1950PubMedCrossRefGoogle Scholar
  12. 12.
    Misra PK, Sharma B: Hypoglycemia in newborns—A prospective study.Indian Pediat 15: 129, 1977Google Scholar
  13. 13.
    Lubchenco LO, Baird H: Incidence of hypoglycemia in newborn infant as classified by birthweight and gestational age.Pediatric 47: 831, 1971Google Scholar
  14. 14.
    Fosbrooke AS, Wharton BA: Plasma lipids in umbilical cord blood from infants of normal and low birth weight.Biol Neonate 23: 330, 1973Google Scholar
  15. 15.
    Christensen NC: Concentrations of triglycerides, free fatty acids and glucose in cord blood of newborn infants with a birth weight of <2700 gm.Acta Pediatr Scand 66: 43, 1977CrossRefGoogle Scholar
  16. 16.
    Prakash P, Saksena S, Joshi KJ, Rai SML: A study of serial estimations of free fatty acids in newborn infants.Ind Pediat 17: 329, 1980Google Scholar
  17. 17.
    Felig P: Maternal and fetal fuel homeostasis in human Pregnancy.Am J Clin Nutr 26: 998, 1973PubMedGoogle Scholar
  18. 18.
    Knopp RH, Saudek CD, Arky RA, O’Sullivan JB: Two phases of adipose tissue metabolism in pregnancy-maternal adaptation for fetal growth.Endocrinology 92: 984, 1973PubMedCrossRefGoogle Scholar
  19. 19.
    Widdowson E: Harmony of growth.Lancet i: 902, 1970Google Scholar
  20. 20.
    Melichar V, Wolf H: Postnatal changes in the blood serum content of glycerol and free fatty acids in premature infants.Biol Neonate 11: 50, 1967CrossRefGoogle Scholar
  21. 21.
    Sinclair J, Saigal S, Young C: Early post natal consequences of fetal nutrition in:Nutrition and Development Winick, M, (ed): John Wiley and Sons Ltd., New York: 1972 p. 147Google Scholar
  22. 22.
    Tsang R, Glueck J, Evans C, Steiner PM: Cord blood hypertriglyceridemia.Am J Dis Child 127: 78, 1974PubMedGoogle Scholar
  23. 23.
    Leeuw RD, Vries IJD: Hypoglycemia in small for date newborns.Pediatrics 58: 18, 1976PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1984

Authors and Affiliations

  • P. K. Misra
    • 1
  • D. K. Tiwari
    • 1
  • B. Sharma
    • 1
  • R. Kaul
    • 1
  1. 1.Department of PediatricsKing George’s Medical CollegeLucknow

Personalised recommendations