Gastroenterologia Japonica

, Volume 17, Issue 3, pp 241–245 | Cite as

Significance of circulating HBs antigen-antibody immune complexes in patients with HBs antigen-positive liver disease

  • Katsuaki Sugiura
  • Yasushi Hasumura
  • Jugoro Takeuchi
Original Articles


The nature of circulating immune complexes (CIC) which appear in patients with type B hepatitis was investigated using a method of Raji cell fluorescent immunoassay. CIC were found in seventeen of thirty-five cases (48.6%) with HBs antigen (HBsAg)-positive liver diseases (4/8 cases with acute hepatitis, 9/18 cases with chronic hepatitis, and 4/9 cases with liver cirrhosis), whereas no CIC were detectable in sera of ten asymptomatic, healthy carriers with HB virus. Among the seventeen cases with CIC-positive liver diseases, HBs antigen-antibody immune complexes (HBsIC) were demonstrated in eleven (65%). A high incidence (54%) of proteinuria was observed in patients with CIC-positive liver diseases compared to those without them (10%). Moreover, 83% of patients with HBsIC were associated with proteinuria. A case of fulminant type B hepatitis showed high titers of both CIC and HBsIC during the acute phase of the disease; in the recovery stage, the titers decreased to within normal ranges.

These results demonstrate that HBsAg is a possible antigen in CIC during type B hepatitis. Determination of serum HBsIC is significant for the clinical evaluation of HB virus-related liver diseases.

Key Words

HBs antigen-antibody immune complexes HBs-positive liver diseases 


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Copyright information

© The Japanese Society of Gastroenterology 1982

Authors and Affiliations

  • Katsuaki Sugiura
    • 1
  • Yasushi Hasumura
    • 1
  • Jugoro Takeuchi
    • 1
  1. 1.The Second Department of Internal Medicine, School of MedicineTokyo Medical and Dental UniversityTokyoJapan

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