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Gastroenterologia Japonica

, Volume 21, Issue 1, pp 23–29 | Cite as

Suppression of immunoglobulin synthesis by activated B cells in chronic active liver diseases and primary biliary cirrhosis

  • Shinichi Kakumu
  • Kazuhiko Fukui
  • Kentaro Yoshioka
  • Hiroshi Murakami
Original Article

Summary

We investigated the suppressor function of peripheral blood B cells from patients with chronic active liver diseases (CALD) and primary biliary cirrhosis (PBC). Suppressor cells were generated by preincubation of B cells with protein A, and suppressive effects were evaluated by inhibition of pokeweed mitogeninduced immunoglobulin (Ig) synthesis of normal peripheral blood lymphocytes (PBL) in second-set cultures. The mean percent suppressions for IgG and IgM synthesis of 12 HBsAg-negative patients with CALD, who were not on prednisone therapy, were lower (p<0.01, respectively) than those of controls. B cells from 6 HBsAg-positive patients with CALD also showed less suppression of IgG and IgM synthesis (p<0.01, respectively). Moreover the suppression for IgG and IgM in 7 patients with PBC were decreased (p<0.01, respectively). There was an inverse correlation between serum gammaglobulin level and percent suppression for IgG synthesis by protein A-activated B cells of patients with CALD (r = -0.50, p<0.05). Further studies demonstrated that protein A-activated B cells were capable of activating the suppressor function of T cells, which could then act to inhibit further B cell differentiation. These results suggest an aberrance of a feedback mechanism that is likely to regulate Ig synthesis in patients with CALD and PBC.

Key Words

Suppressor B cell Protein A Chronic liver disease 

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Copyright information

© The Japanese Society of Gastroenterology 1986

Authors and Affiliations

  • Shinichi Kakumu
    • 1
  • Kazuhiko Fukui
    • 1
  • Kentaro Yoshioka
    • 1
  • Hiroshi Murakami
    • 1
  1. 1.Third Department of MedicineNagoya University School and MedicineNagoyaJapan

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