Gastroenterologia Japonica

, Volume 28, Issue 1, pp 18–24 | Cite as

Interleukin 6 production by peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection and primary biliary cirrhosis

  • Shinichi Kakumu
  • Tadashi Shinagawa
  • Tetsuya Ishikawa
  • Kentaro Yoshioka
  • Takaji Wakita
  • Nobuo Ida
Liver, Pancreas and Biliary Tract


IL-6 production by peripheral blood mononuclear cells (PBMC) was studied in patients with chronic hepatitis B virus (HBV) infection and primary biliary cirrhosis (PBC) using the ELISA method. Spontaneous production of IL-6 was significantly increased in patients with HBeAg+ chronic hepatitis (CH). The cultures stimulated with lipopolysaccharide and lectin-free interleukin-2 (IL-2) showed enhanced IL-6 production both in controls and all patient groups compared with culture without any stimulation. IL-6 production in response to IL-2 was higher in patients with HBeAg+ CH and PBC than in controls. In PBMC with increased IL-6 production, monocyte function was increased in patients with HBeAg+ CH and PBC, while B cells from PBC showed elevated response to Staphylococcus aureus Cowan 1. IL-6 production in the presence of HBeAg was greater in anti-HBe+ patients than in HBeAg+ ones. These results suggest that IL-6 response is involved in the immune response in patients with chronic liver disease.

Key words

IL-6 production chronic hepatitis B PBC 


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Copyright information

© The Japanese Society of Gastroenterology 1993

Authors and Affiliations

  • Shinichi Kakumu
    • 1
  • Tadashi Shinagawa
    • 1
  • Tetsuya Ishikawa
    • 1
  • Kentaro Yoshioka
    • 1
  • Takaji Wakita
    • 1
  • Nobuo Ida
    • 2
  1. 1.Third Department of Internal MedicineNagoya University School of MedicineNagoyaJapan
  2. 2.Basic Research LaboratoriesToray Industries, Inc.KamakuraJapan

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