Gastroenterologia Japonica

, Volume 18, Issue 4, pp 310–313 | Cite as

Morphological study on the motility of the human colon

  • Norimasa Narita
  • Kiyoshi Kawakami
  • Yutaka Yoshida
  • Goyo Koya
Original Article


We tried to make a clear three-dimensional picture of the autonomic nerves in the wall of the human colon, using a Golgi method rarely applied to human materials. At autopsy, sigmoid colon without mucosal lesions were collected from 16 males after sudden death from apoplexy, head injury, or myocardial infarction. These materials were fixed in 10% formalin, impregnated with a modified Golgi method and embedded in celloidin. Then three-dimensional serial sections were made and observed with a light microscope. Many fine nerve fibers formed a plexus in the subserosa, muscular layer, submucosa, and mucosa. The myenteric plexus was made up of rectangular meshes of nerve fiber bundles. However, unlike myenteric plexus, no regular mesh was found in the submucosal plexus. Further, nerve fibers connecting myenteric and submucosal plexus were observed. It may be concluded from these findings that there exist nerve pathways regulating intestinal motility between myenteric and submucosal plexus.

Key Words

intrinsic nerves Golgi method threedimensional picture human colon 


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  1. 1).
    Fukuhara T, et al: On the intestinal intrinsic reflexes. Jpn J Physiol 8: 9, 1958Google Scholar
  2. 2).
    Schofield GC: Anatomy of muscular and neural tissues in the alimentary canal, in “Handbook of Physiology” Sec 6, Alimentary Canal, 4, Motility, by Code CF, Am Physiol Soc, Washington DC 1968, p 1579Google Scholar
  3. 3).
    Baumgarten HG, et al: Auerbach’s plexus of mammals and man: Electron microscopic identification of three different types of neuronal processes in myenteric ganglia of the large intestine from rhesus monkeys, guinea-pigs and man. Z Zellforsch 106: 376, 1970PubMedCrossRefGoogle Scholar
  4. 4).
    Gershon MD: The enteric nervous system: Multiplicity of neurotransmitters outside of the brain, in “Smooth Muscle” by Bülbring E, Brading AF, Jones AW, Tomita T. Arnold, London 1981, p 263Google Scholar
  5. 5).
    Truelove SC: Movements of the large intestine. Physiol Rev 46: 457, 1966PubMedGoogle Scholar
  6. 6).
    Parks TG: Colonic motility in man. Postgraduate Med J 49:90, 1973CrossRefGoogle Scholar
  7. 7).
    Christensen J: Myoelectric control of the colon. Gastroenterology 68: 601, 1975PubMedGoogle Scholar
  8. 8).
    Snape WJ, et al: Colonic myoelectric activity in the irritable bowel syndrome. Gastroenterology 70: 326, 1976PubMedGoogle Scholar
  9. 9).
    Sasaki D, et al: Antispasmodic effect of prifinium bromide on the proximal and distal colon in patients with diverticular disease. Gastroenterologia Jpn 16: 344, 1981Google Scholar
  10. 10).
    Golgi C: Sulla structura della sostanza grigia del cervello. Gazzetta Medica Italiana 33: 244, 1873Google Scholar
  11. 11).
    Braitenberg V, et al: Morphological observations on the cerebellar cortex. J Comparative Neurol 109: 1, 1958CrossRefGoogle Scholar
  12. 12).
    Braitenberg V, et al: Correlation of crystal growth with the staining of axons by the Golgi procedure. Stain Techn 42: 277, 1967PubMedGoogle Scholar
  13. 13).
    Narita N, et al: Formalin fixed material and modified Golgi staining. Hirosaki Med J 32: 191, 1980 (Jpn)Google Scholar
  14. 14).
    Koya G, et al: Rapid method of embedding with celloidin. Hirosaki MedJ 32: 156, 1980 (Jpn)Google Scholar
  15. 15).
    Hirst GDS, et al: Two descending nerve pathways activated by distension of guinea-pig small intestine. J Physiol 244: 113, 1975PubMedGoogle Scholar
  16. 16).
    Hirst GDS, et al: Synaptic potentials recorded from neurones of the submucous plexus of guinea-pig small intestine. J Physiol 249: 369, 1975PubMedGoogle Scholar
  17. 17).
    Ohkubo K: Studies on the intrinsic nervous system of the digestive tract. I. The submucous plexus of guinea-pig. Jpn J Med Sci, 1 Anatomy 6: 1, 1936Google Scholar
  18. 18).
    Fehèr E: Ultrastructural study of nerve terminals in the submucous plexus and mucous membrane after extirpation of the myenteric plexus. Acta Anat 94: 78, 1976PubMedGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1983

Authors and Affiliations

  • Norimasa Narita
    • 1
  • Kiyoshi Kawakami
    • 1
  • Yutaka Yoshida
    • 1
  • Goyo Koya
    • 2
  1. 1.First Department of Internal MedicineHirosaki University School of MedicineHirosakiJapan
  2. 2.Department of Pathology, Institute of Cere brovascular DiseasesHirosaki University School of MedicineHirosakiJapan

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