Advertisement

Gastroenterologia Japonica

, Volume 15, Issue 2, pp 120–127 | Cite as

Studies on the etiologic mechanism of anisakiasis

I. Immunological reactions of digestive tract induced byAnisakis Larva
  • Kazuaki Asaishi
  • Chisato Nishino
  • Toshiaki Ebata
  • Morio Totsuka
  • Hiroshi Hayasaka
  • Toshio Suzuki
Original Article

Summary

In an attempt to determine the etiological mechanism of anisakiasis, immunological studies were performed using guinea pigs and rabbits. In order to carry out these examinations, we used a specific antigen, hemoglobin ofAnisakis larva. We demonstrate that the etiological mechanism of anisakiasis involves anaphylactic reaction as well as Arthus reaction in the digestive tract. Cell-mediated immune reaction also have to consider the relation of establishment of allergic condition in experimental anisakiasis. These results suggest that the three types allergic reaction may play the main role in clinical symptomes of human anisakiasis.

Key Words

Anisakis larva hemoglobin of Anisakis larva Arthus reaction anaphylactic reaction cell-mediated immune reaction 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Asaishi K, et al: Epidemiology of anisakiasis. Jpn Med J 2676: 30, 1975. (Jpn)Google Scholar
  2. 2).
    Nishino C: Epidemiological studies on anisakiasis. Sapporo Med J 46: 73, 1977. (Jpn)Google Scholar
  3. 3).
    Suzuki T: Immunodiagnosis of anisakiasis, with special reference to purification of specific antigen. Chinese J Microbiol 4: 217, 1971Google Scholar
  4. 4).
    Asaishi K: Antigenic analysis ofAnisakis larva and application of fluorescent antibody technique to histological diagnosis of anisakiasis. Sapporo Med J 43: 104, 1974. (Jpn)Google Scholar
  5. 5).
    Sato Y, et al: Studies on the etiologic mechanism of anisakiasis 1. The anaphylactic reaction of digestive tract to the worm extracts. Jpn J Parasitai 24: 192, 1975. (Jpn)Google Scholar
  6. 6).
    Shore PA, et al: A method for the fluorometric assay of histamine in tissue. J Pharmacol Exp 127: 182, 1959Google Scholar
  7. 7).
    Udenfriend S, et al: Fluorescence characteristics of 5-hydroxytryptamine (serotonin). Science 122: 972, 1955PubMedCrossRefGoogle Scholar
  8. 8).
    Saeki H: Studies on cell-mediated immunity in experimental anisakiasis. Sapporo Med J 44: 309, 1975. (Jpn)Google Scholar
  9. 9).
    Asaishi K, et al: Studies on the etiologic mechanism of anisakiasis. Antibody production and histological changes of digestive tract induced by injection of the insolubled worm extracts. Jpn J Parasitol 27: 65, 1978. (Jpn)Google Scholar

Copyright information

© The Japanese Society of Gastroenterology 1980

Authors and Affiliations

  • Kazuaki Asaishi
    • 1
  • Chisato Nishino
    • 1
  • Toshiaki Ebata
    • 1
  • Morio Totsuka
    • 1
  • Hiroshi Hayasaka
    • 1
  • Toshio Suzuki
    • 2
  1. 1.The First Department of SurgerySapporo Medical College & HospitalSapporoJapan
  2. 2.Department of ParasitologyAkita University School of MedicineAkitaJapan

Personalised recommendations