Summary
To study the intestinal phase of ulcer inhibition, olive oil or hydrochloric acid was infused into small intestine in white male rats weighing 200–250 gr. The animals were fasted before study. Tetragastrin was administered continuously through the tail vein using the infusion pump. The ulcer formation by gastrin at the rate of 60% was decreased by the oil or hydrochloric acid infused into small intestine as well as by secretin administered intravenously (8 U/kg-h). The acid output and the rate of secretory volume were also inhibited by oil, HCl and secretin. Peptic output by gastrin was decreased by infusing the hydrochloric acid into small intestine, however olive oil in small intestine neither decreased nor augmented the peptic putout. Through these results the important role of small intestine in the inhibitory system of ulcerogenesis became obvious. To make clear the hyperacidity as one of the ethiological factors of peptic ulcer, the intestinal phase of gastric acid secretion should be investigated especially by the study of gastrointestinal hormone.
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References
Shinozaki, F.: Experimental Gastroduodenal Uleer Induced by Tetragastrin (in Japanese). Jap. J. Gastroent. 69: 359–376, 1972.
Segawa, K.: The Studies on the Inhibitory Activity of Secretin and Gastrone upon Gastrin Ulcerogenesis (in Japanese). Jap. J. Gastroent, 69: 474–490, 1972.
Kosaka, K. et al: Demonstration of Humoral Agent in the Fat Inhibition of Gastric Secretion. Proc.Exp.Biol., 27: 890, 1930.
Johnson, L. R et al: Intestinal Hormones as an Inhibitors of Gastric Secretion. Gastroent, 60: 120, 1971.
Buchanan, K. D. et al.: Glucagon in the Gut. Gut, 12: 861, 1971.
Shinozaki, F., Nakazawa, S., Odori, Y., Kitamura, K., Segawa, K. et al: A Device of Automatic Gastric Juice Collector for Experimental Use (in Japanese). Igaku No aAyumi, 77: 280–281, 1971.
Hunt, J. N.: A Methiod for Estmation of Peptic Activity in Gastric Contents, Biochem. J., 42: 104, 1947.
Odori, Y.: A Clinical and Histological Study of the Gastric Secretion Induced by Gastrin Tetrapeptide (in Japanese). Jap. J. Gastroent. 68; 146, 1971.
Hanson, M.E. et al: Production of Gastroduodenal Ulcer in the Dog by Continuos Subcutaneous or Intravenous Administration of Histamine. Surgery, 24: 499, 1949.
Grossman, M. I., Gastrin, London, Butterworth, 1966.
Emas, S. et al: Production of Dudoenal Ulcers by Infusion of the Porcine Gastrin, Gastroent., 52: 959, 1967.
Robert, A. et al: Production of Secretagogues of Duodenal Ulcers in the Rat. Gastroent., 59: 95, 1970.
Gobbel, W. G. et al: Production of Duodenal Ulcers by Exogenous Gastrin, Amer. J. Surg., 113: 183, 1967.
Konturek, S. J. et al: The Effect of Secretin on Gastric Acid Secretion and Peptic Ulcers Induced by Pentagastrin in Cats with Intact or Resected Duodenum. Amer. J. Dig. Dis., 13: 874, 1968.
Berson, S.A. et al: Radioimmunoassay in Gastroenterology. Gastroent. 62: 1061, 1972.
Landner, J. H. et al: Gastric Hypersecretion Produced by Massive Small Bowel Resection in Dogs. J. Surg. Res., 518, 1964.
Fujita, T.: GEP endocrine system-A cell biological approach, Tokyo, Igaku Shoin Ltd., 1973.
Prearse, A. G. E. et al: The Ednocrine Polypeptide Cells of the Human Stomach, Duodenum and Jejunum. Gut: II: 649–658 1970.
Brown, J. C. et al: Further Purification of a Polypeptide Demonstrating Enterogastrone Activity. J. Pyhsiol., 209: 57, 1970.
Baume, P. E. et al: Concentration and Partial Characterization of Human Salivary Gastrone. Amer. J. Dig. Dis., 12: 965, 1967.
Gregory, H.: Some Polypeptide Influencing Gastric Acid Secretion. Amer. J. Dig. Dis., 15: 141, 1970.
Fiasse, R. et al: Fractionation and Partial Purification of Gastrone. Gastroent., 54: 1018, 1968.
Konturek, S.J. et al: Effect of Perfusion of Intestional Loops with Acid, Fat or Dextrose on Gastric Secretion. Gastroent., 49: 481–489, 1965.
Brooks, A.M. et al: The Effect of Secretin and Duodenal Acidification on Pepsin Secretion in Man. Gastroent. 57: 159, 1969.
Nakajima, S. et al: Influence of Duodenal Acidification of Acid and Pepsin of the Stomach in Dogs. Amer. J. Physiol., 218: 545–549, 1970.
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Segawa, K., Nakazawa, S., Odori, Y. et al. The inhibition of gastrin induced duodenal ulcer by fat or acid in small intestine. Gastroenterol Jpn 9, 253–260 (1974). https://doi.org/10.1007/BF02774791
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DOI: https://doi.org/10.1007/BF02774791