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Gastroenterologia Japonica

, Volume 9, Issue 3, pp 253–260 | Cite as

The inhibition of gastrin induced duodenal ulcer by fat or acid in small intestine

  • Kose Segawa
  • Saburo Nakazawa
  • Yasuhiko Odori
  • Toshiyuki Hattori
  • Yasuo Naito
  • Eisaku Ochiai
  • Furtiio Mizuno
  • Kenji Imai
  • Hiroshi Nakano
  • Mitsuo Ishiguro
  • Nobuo Matsuo
  • Yoshiki Yamamoto
  • Masao Shiohara
  • Naozo Kamiya
  • Kunio Sobue
  • Hirohiko Yamase
  • Kenichi Yamada
Original Article
  • 5 Downloads

Summary

To study the intestinal phase of ulcer inhibition, olive oil or hydrochloric acid was infused into small intestine in white male rats weighing 200–250 gr. The animals were fasted before study. Tetragastrin was administered continuously through the tail vein using the infusion pump. The ulcer formation by gastrin at the rate of 60% was decreased by the oil or hydrochloric acid infused into small intestine as well as by secretin administered intravenously (8 U/kg-h). The acid output and the rate of secretory volume were also inhibited by oil, HCl and secretin. Peptic output by gastrin was decreased by infusing the hydrochloric acid into small intestine, however olive oil in small intestine neither decreased nor augmented the peptic putout. Through these results the important role of small intestine in the inhibitory system of ulcerogenesis became obvious. To make clear the hyperacidity as one of the ethiological factors of peptic ulcer, the intestinal phase of gastric acid secretion should be investigated especially by the study of gastrointestinal hormone.

Key words

gastrin, secretin duodenal ulcer gastro-intestinal hormone gastric secretion 

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Copyright information

© The Japanese Society of Gastroenterology 1974

Authors and Affiliations

  • Kose Segawa
    • 1
  • Saburo Nakazawa
    • 1
  • Yasuhiko Odori
    • 1
  • Toshiyuki Hattori
    • 1
  • Yasuo Naito
    • 1
  • Eisaku Ochiai
    • 1
  • Furtiio Mizuno
    • 1
  • Kenji Imai
    • 1
  • Hiroshi Nakano
    • 1
  • Mitsuo Ishiguro
    • 1
  • Nobuo Matsuo
    • 1
  • Yoshiki Yamamoto
    • 1
  • Masao Shiohara
    • 1
  • Naozo Kamiya
    • 1
  • Kunio Sobue
    • 1
  • Hirohiko Yamase
    • 1
  • Kenichi Yamada
    • 1
  1. 1.2nd Dept. of Int. Med.Nagoya University School of MedicineNagoya CityJapan

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