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Gastroenterologia Japonica

, Volume 17, Issue 1, pp 15–20 | Cite as

Rotor’s syndrome: A study on variations in pigment metabolism with age

  • Hidemasa Okumura
  • Noboru Fukuda
  • Takumi Aramaki
  • Yasumi Katsuta
  • Katsuaki Satomura
  • Tadanobu Sato
  • Tsuyoshi Yano
Original Articles
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Summary

The effects of aging on the pigment metabolism in Rotor’s syndrome were investigated in six cases examined at least twice at an average interval of 10.5 ±6.5 years and additional four cases examined only once. No significant increase was found in the total (TB) or direct (DB) bilirubin in serum. However, indirect bil rubin increased significantly from 1.21 ± 0.72 mg/dl to 2.28 ± 1.00 mg/dl (p<0.05) and DB/TB ratio (% Direct) decreased significantly from 77.3 ± 6.6% to 64.4 ± 8.7% (p<0.05). BSP retentions at 45 minutes increased significantly from 26.8 ± 10.9% to 45.3 ± 14.9% (p<0.05). A significant positive correlation between the values of BSP retained at 45 minutes and the age was also observed (p<0.01). These results suggest that the pigment metabolism in Rotor’s syndrome deteriorates with the age.

Key words

Rotor’s syndrome BSP bilirubin aging 

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Copyright information

© The Japanese Society of Gastroentrology 1982

Authors and Affiliations

  • Hidemasa Okumura
    • 1
  • Noboru Fukuda
    • 1
  • Takumi Aramaki
    • 1
  • Yasumi Katsuta
    • 1
  • Katsuaki Satomura
    • 1
  • Tadanobu Sato
    • 1
  • Tsuyoshi Yano
    • 1
  1. 1.The First Department of Internal Medicine and Department of Clinical PathologyNippon Medical SchoolTokyoJapan

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