Gastroenterologia Japonica

, Volume 20, Issue 4, pp 338–343 | Cite as

Biliary squalene levels in hepatobiliary disease

  • Yasuo Nosaka
  • Yasuhito Yamanishi
  • Chisato Hirayama
Original Article


Following overnight fasting, biliary levels of squalene, bile salts, cholesterol and phospholipid were estimated using human bile obtained with a duodenal double lumen catheter after administration of caerulein. While the squalene level in B-bile was 6.86 μM in the control group, it fell significantly in patients with parenchymal liver diseases, especially liver cirrhosis. There was no significant change in the level in patients with cholelithiasis. Biliary squalene concentration showed a significant correlation with concentrations of bile salts, cholesterol and phospholipid. These results substantiate the possibility that the biliary squalene level reflects sterol metabolism in the liver.

Key words

Squalene Bile salts Cholesterol Phospholipid Hepatobiliary disease 


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Copyright information

© The Japanese Society of Gastroenterology 1985

Authors and Affiliations

  • Yasuo Nosaka
    • 1
  • Yasuhito Yamanishi
    • 2
  • Chisato Hirayama
    • 1
  1. 1.The Second Department of Internal MedicineTottori University School of MedicineYonagoJapan.
  2. 2.Department of Internal MedicineTanabe National HospitalTanabeJapan

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