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Biliary squalene levels in hepatobiliary disease

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Summary

Following overnight fasting, biliary levels of squalene, bile salts, cholesterol and phospholipid were estimated using human bile obtained with a duodenal double lumen catheter after administration of caerulein. While the squalene level in B-bile was 6.86 μM in the control group, it fell significantly in patients with parenchymal liver diseases, especially liver cirrhosis. There was no significant change in the level in patients with cholelithiasis. Biliary squalene concentration showed a significant correlation with concentrations of bile salts, cholesterol and phospholipid. These results substantiate the possibility that the biliary squalene level reflects sterol metabolism in the liver.

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Authors and Affiliations

  1. The Second Department of Internal Medicine, Tottori University School of Medicine, 36-1 Nishimachi, 683, Yonago, Japan.

    Yasuo Nosaka M.D. & Chisato Hirayama M.D.

  2. Department of Internal Medicine, Tanabe National Hospital, 646, Tanabe, Japan

    Yasuhito Yamanishi M.D.

Authors
  1. Yasuo Nosaka M.D.
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  2. Yasuhito Yamanishi M.D.
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  3. Chisato Hirayama M.D.
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Nosaka, Y., Yamanishi, Y. & Hirayama, C. Biliary squalene levels in hepatobiliary disease. Gastroenterol Jpn 20, 338–343 (1985). https://doi.org/10.1007/BF02774744

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  • DOI: https://doi.org/10.1007/BF02774744

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