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Gastroenterologia Japonica

, Volume 18, Issue 2, pp 93–97 | Cite as

Liquid crystal formation in ursodeoxycholate-rich human gallbladder bile

  • Hirotsune Igimi
  • Shohei Asakawa
  • Daisuke Watanabe
  • Hidehiko Shimura
Original Article
  • 24 Downloads

Summary

We studied liquid crystal formation in bile samples obtained from the patients with radiolucent gallstones who had been administered either ursodeoxycholic acid (UDCA) at a dose of 600 mg/day or chenodeoxycholic acid (CDCA) at 400 mg/day for one week preoperatively. The UDCA/total bile acids ratio was found to range from 50 to 60% and the CDCA/total bile acids ratio ranged from 70 to 80%. Cholesterol molar percent was 5 in UDCA-rich bile and 6 in CDCA-rich bile. Phospholipid molar percentage was about the same in both groups. Liquid crystal formation was confirmed only in the UDCA-rich bile samples but not in the CDCA-rich bile samples. This result suggests that cholesterol in the UDCA-rich bile samples is not solubilized by the bile salt and phospholipid mixed micells but also consumed to form liquid crystals.

Key words

ursodeoxycholic acid chenodeoxycholic acid phospholipid, liquid crystal spherical droplets 

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Copyright information

© The Japanese Society of Gastroenterology 1983

Authors and Affiliations

  • Hirotsune Igimi
    • 1
  • Shohei Asakawa
    • 1
  • Daisuke Watanabe
    • 1
  • Hidehiko Shimura
    • 1
  1. 1.First Department of Surgery, School of MedicineFukuoka UniversityJohnan-ku, FukuokaJapan

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