Gastroenterologia Japonica

, Volume 21, Issue 5, pp 508–512 | Cite as

Granular cell tumor of the esophagus

  • Koichi Miwa
  • Takanori Hattori
  • Youhei Hosokawa
  • Yasutaka Nakamura
  • Yoshiaki Isobe
  • Katsunori Fujisawa
  • Gizou Nakagawara
Case Report


A case of granular cell tumor of the esophagus in a 50-year-old man is reported. Gastrointestinal endoscopy revealed a round, sessile, non-ulcerated white-yellow elevated tumor at the lower third of the esophagus. Biopsy revealed a granular cell tumor. Immunohistochemical staining demonstrated that granules in the cytoplasm of tumor cells were positive for S-100 protein and negative for carcinoembryonic antigen. An electron microscopic study revealed that tumor cells were closely packed in clusters, surrounded by basal lamina and collagen fibers. Most cells contained dark cytoplasm filled with electrondense granules. These granules resembled lysosomes and phagosomes. In a few cells with clear cytoplasm, some mitochondria and poorly developed endoplasmic reticulums were seen. Fibrillar internal materials, myelin-like figures and a premature angulate body were observed in the clear cytoplasm. The lesion has remained unchanged in gross appearance and in size for twenty-three months without any treatment.

Key Words

Esophageal submucosal tumor Gastrointestinal endoscopy Granular cell myoblastoma Granular cell tumor Immunohistochemistry Ultrastructure 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Abrikossoff AI: Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch [Pathol Anat] 260: 215, 1926CrossRefGoogle Scholar
  2. 2).
    Subramanyam K, et al: Granular cell myoblastoma of the esophagus. J Clin Gastroenterol 6: 113, 1984PubMedCrossRefGoogle Scholar
  3. 3).
    Abrikossoff AI: Weitere Untersuchungen über Myoblastenmyome. Virchows Arch [Pathol Anat] 280: 723, 1931CrossRefGoogle Scholar
  4. 4).
    Fust JA, et al: On neurogenesis of so-called granular cell myoblastoma. Am J Clin Pathol 19: 522, 1949PubMedGoogle Scholar
  5. 5).
    Bangle R: A morphological and histochemical study of the granular-cell myoblastoma. Cancer 5: 950, 1952PubMedCrossRefGoogle Scholar
  6. 6).
    Fisher ER, et al: Granular cell myoblastoma—a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwannoma). Cancer 15: 936, 1962PubMedCrossRefGoogle Scholar
  7. 7).
    Rode J, et al: Immunohistochemical staining of granular cell tumour for neurone spacific enolase: Evidence in support of a neural origin. Diagn Histopathol 5: 205, 1982PubMedGoogle Scholar
  8. 8).
    Nakazato Y, et al: Immunohistochemical localization of S-100 protein in granular cell myoblastoma. Cancer 49: 1624, 1982PubMedCrossRefGoogle Scholar
  9. 9).
    Armin A, et al: An immunoperoxidase investigation of S-100 protein in granular cell myoblastomas: Evidence for Schwann cell derivation. Am J Clin Pathol 79: 37, 1983PubMedGoogle Scholar
  10. 10).
    Bedetti CD, et al: Granular cell tumor arising in myelinated peripheral nerves: light and electron microscopy and immunoperoxidase study. Virchows Arch [Pathol Anat] 402: 175, 1983CrossRefGoogle Scholar
  11. 11).
    Aparicio SR, et al: Light-and electron-microscope studies on the granular cell myoblastoma of the tounge. J Pathol 97: 339, 1969PubMedCrossRefGoogle Scholar
  12. 12).
    Garancis JC, et al: Granular cell myoblastoma. Cancer 25: 542, 1970PubMedCrossRefGoogle Scholar
  13. 13).
    Sobel HJ, et al: Light-and electron-microscope study of the origin of granular-cell myoblastoma. J Pathol 109: 101, 1973PubMedCrossRefGoogle Scholar
  14. 14).
    Pour P, et al: Granular cells in tumors and in nontumorous tissue. Arch Pathol 95: 135, 1973PubMedGoogle Scholar
  15. 15).
    Swerdlow MA, et al: Pseudoepitheliomatous hyperplasia associated with myoblastoma: a diagnostic pittfall. US Armed Forces Med J 5: 831, 1954Google Scholar
  16. 16).
    Miller AS, et al: Oral granular-cell tumors: report of twenty-five cases with electron microscopy. Oral Surg 44:227, 1977PubMedCrossRefGoogle Scholar
  17. 17).
    Caputo R, et al: Ultrastructure of the granular cell myoblastoma: so-called Abrikossoff’s tumor. Arch Dermatol Forsch 242: 127, 1972PubMedCrossRefGoogle Scholar
  18. 18).
    Miettinen M, et al: Histogenesis of granular cell tumor —An immunohistochemical and ultrastructural study. J Pathol 142: 221, 1984PubMedCrossRefGoogle Scholar
  19. 19).
    Gamboa LG: Malignant granular-cell myoblastoma. A M A Arch Pathol 60: 663, 1955Google Scholar
  20. 20).
    Robertson AJ, et al: Malignant granular cell tumour (myoblastoma) of the vulva: report of a case and review of the literature. Histopathology 5: 69, 1981PubMedCrossRefGoogle Scholar
  21. 21).
    Steffelaar JW, et al: Malignant granular cell tumor: report of a case with special reference to carcinoembryonic antigen. Am J Surg Pathol 6: 665, 1982PubMedCrossRefGoogle Scholar
  22. 22).
    Crawford ES, et al: Granular-cell myoblastoma: two unusual cases. Cancer 6: 786, 1953PubMedCrossRefGoogle Scholar
  23. 23).
    Obiditsch-Mayer I, et al: Malignes “gekörntzelliges Neurom”, sogenanntes “Myoblastenmyom”, des Oesophagus. Beitr Path Anat 125: 357, 1961Google Scholar
  24. 24).
    Cone JB, et al: Esophageal granular cell tumors: report of two multicentric cases with observations on their natural histories. J Surg Oncol 20: 14, 1982PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1986

Authors and Affiliations

  • Koichi Miwa
    • 1
  • Takanori Hattori
    • 2
  • Youhei Hosokawa
    • 2
  • Yasutaka Nakamura
    • 1
  • Yoshiaki Isobe
    • 1
  • Katsunori Fujisawa
    • 1
  • Gizou Nakagawara
    • 1
  1. 1.First Department of SurgeryFukui Medical SchoolFukuiJapan
  2. 2.First Department of PathologyFukui Medical SchoolFukuiJapan

Personalised recommendations