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A Study of intragastric ph in patients with peptic ulcer-with special reference to the clinical significance of basal pH value

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Summary

Determination was made of in situ gastric pH during early morning in fasting state (basal pH) by using wired glass electrodes, and results obtained were analyzed.

Analysis of the pattern of variation in intragastric pH at night revealed no substantial difference between normal subjects and patients with peptic ulcer but a tendency to be lower in the latter group. It was also shown that sleeping waves appeared in the electroencephalogram in association with the increase in intragastric pH during sleep at night.

The basal pH value was 5.4 ±2.1 in patients with gastric cancer, 3.0 ±2.2 in those with gastritis, 2.4 ±1.9 in those with gastric ulcer, 1.7 ±0.2 in normal subjects and 1.3 ±0.6 in patients with duodenal ulcer. In gastric ulcer patients more anal site of ulcer lesion was associated with lower mean age of the patients and higher incidence of intestinal metaplastic gastritis of the antral or non-metaplastic type.

In patients who underwent partial gastrectomy for peptic ulcer, the pH value in the remnant stomach tended to become higher with the lapse of time in all cases, being constant at about 3 months postoperatively. The decrease in gastric acidity at 12 months after operation was incomplete in patients who underwent emergency gastrectomy for perforated duodenal ulcer but satisfactory in those who underwent selective vatotomy and anterectomy as elective operations.

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References

  1. Jacobson B, Mackay RS: A pH-endoradiosonde. Lancet I: 1224, 1957

    Article  Google Scholar 

  2. Nöller HG: Clinical applications of telemetaring technique. Proc of the 3rd Int Conf On ME, London, pp 111–114,1960

  3. Watanuki T: Clinical use of capsule. Jikei Med J 79: 456–466, 1965 (Jpn)

    Google Scholar 

  4. Watanuki T: Clinical use of capsule in digestive tract. J CIin Surg 23: 800–811, 1968 (Jpn)

    Google Scholar 

  5. Yoshizawa R: Studies on the gastric function by telemetering endo-radio-capsule. -clinical application of a pH measuring capsule. Jpn J Gastroenterology 66: 456–473, 1969 (Eng Abstr)

    Google Scholar 

  6. Kawai K: Study on the intragastric pH by a radio telemetering capsule-gastric function tests by loading small dose of sodium bicarbonate into the stomach. J Jpn Surg Soc 71: 482 -509, 1970 (Jpn)

    Google Scholar 

  7. Koizumi H: Study on in-situ pH values in the esophagus and in the remnant stomach of patients with postoperative complaints. Jpn J Gastroent Surg 11: 198–209, 1978 (Eng Abstr)

    Article  Google Scholar 

  8. Machida T, Kawai K, Watanuki T, et al: Development of glass electrodes for measurement intragastric pH values and its clinical uses. Jpn JMEBE 18: 138–139, 1980 (Jpn)

    Google Scholar 

  9. Moore EW: Determination of pH by the glass electrode: pH meter calibration for gastric analysis. Gastroenterology 54: 501–507, 1968

    CAS  PubMed  Google Scholar 

  10. Sano R: Surgical pathology of gastric diseases. 1st Edition, Tokyo, Igaku Shoin; pp 139–205, 1974 (Jpn)

    Google Scholar 

  11. Koide N: A study of the changes in pH of gastric contents during twenty-four hours by using radiotelemetering capsule. Jpn J Gastroenterol 70: 355–350, 1973 (Eng Abstr)

    Google Scholar 

  12. Segawa K, Nakazawa S, Naito Y, et al: Relationship between gastric pH in night and sleeping. Jpn J Gastroenterology 72: 1216–1217, 1975 (Jpn)

    Google Scholar 

  13. James AH, Pickering GW: The role of gastric acidity in the pathogenesis of peptic ulcer. Clin Sci 8: 181–210, 1949

    CAS  PubMed  Google Scholar 

  14. Watokinson G: A study of the changes in pH of gastric contents in peptic ulcer using the twenty-four hour test meal. Gastroenterology 18: 377–390, 1951

    Google Scholar 

  15. Levin E, Kirsner JB, Palter WL, et al: Nocturnal gastric secretion. Arch Surg 56: 545–356, 1948

    Article  Google Scholar 

  16. Adachi H, Machida T, Kawai K, et al: Test for completeness of vagotomy during operation. Igaku no ayumi 106: 716–717, 1978 (Jpn)

    Google Scholar 

  17. Armstrong RH, Burnap D, Jacobson A, et al: Dreams and gastric secretions in duodenal ulcer patients. New physician 33: 241–243, 1965

    Google Scholar 

  18. Orr WC, Hall WH, Stahl MI, et al: Sleep patterns and gastric acid secretion in duodenal ulcer disease. Arch Intern Med 136: 655–660, 1976

    Article  CAS  PubMed  Google Scholar 

  19. Moore JG, Englert E Jr: Circadian rhythm of gastric acid secretion in man. Nature 226: 1261–1262, 1970

    Article  CAS  PubMed  Google Scholar 

  20. Okuma T: Sleep-physiology and clinical problems. 1st Edition, Tokyo, Igaku -shoin; pp 59–76, 1977 (Jpn)

    Google Scholar 

  21. Stacher G: Zur Frage der Magensäuresekretion im Schlaf Wien Klin. Wochenschr 85: 702–706, 1973

    CAS  Google Scholar 

  22. Makhlouf GM, MacmanusJPA, Card WI: A quantitative Statement of the two-component hypothesis of gastric secretion. Gastroenterology 51: 149–171, 1966

    CAS  PubMed  Google Scholar 

  23. Boury G, Mathey JC, Gautier MC, et al: The pH of the stomach in the preand postoperative assessment of gastroduodenal ulcer, with a statistical study of 206 assays. Ann Chir 29: 545–548, 1975

    CAS  PubMed  Google Scholar 

  24. Bauer AR, Elliott DW, Zollinger RM: Free gastric acid following hemigastrectomy with vagotomy. Ann Surg 154: 281–287, 1961

    Article  PubMed  PubMed Central  Google Scholar 

  25. Gjeruldsen ST, Myren J, Fretheim B: Alterations of gastric mucosa following a graded partial gastrectomy for duodenal ulcer. Scand J Gastroent 3: 465–470, 1968

    Article  CAS  PubMed  Google Scholar 

  26. Melrose AG, Russell RI, Dick A: Gastric muccosal structure and function after vagotomy. Gut 5: 546–549, 1964

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Olbe L: Difference between human and animal gastric acid secretion. Syllabus for AGA post graduate course on peptic ulcer diseases. San Francisco 1974

  28. Koizumi Y, Machida T, Kawai K, et al: Clinical study on patients with stomal ulcer. Jpn J Gastroent Surg 11: 290–296, 1978 (Eng Abstr)

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. The 1st Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, 105, Tokyo, Japan

    Takashi Machida M.D.

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  1. Takashi Machida M.D.
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Machida, T. A Study of intragastric ph in patients with peptic ulcer-with special reference to the clinical significance of basal pH value. Gastroenterol Jpn 16, 447–458 (1981). https://doi.org/10.1007/BF02774516

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  • DOI: https://doi.org/10.1007/BF02774516

KeyWords

nocturnal pH

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