Gastroenterologia Japonica

, Volume 21, Issue 6, pp 617–622 | Cite as

Elevated levels of serum pancreatic secretory trypsin inhibitor (PSTI) in patients with malabsorption syndrome

  • Itsuro Nakano
  • Akihiro Funakoshi
  • Toshinari Kimura
  • Yasuji Miyata
  • Shunichi Koga
  • Hiroshi Ibayashi
Original Article


Serum pancreatic secretory trypsin inhibitor (PSTI) was measured by radioimmunoassay in 5 patients with malabsorption syndrome. The serum level of PSTI was elevated to 123.8 ±25.8 ng/ml (Mean ±SE) in patients with malabsorption syndrome, which was significantly higher than the 16.6 ±0.7 ng/ml level seen in 116 healthy control subjects. Serum PSTI levels in 5 patients with malabsorption syndrome showed inverse correlations with serum levels of cholesterol, cholinesterase and amylase, and not with serum levels of vitamin E, carotene, apoprotein A-IV, albumin, nor with immunoreactive elastase 1, respectively. These results suggest that elevated levels of serum PSTI represent a state of malnutrition due to impaired intestinal absorption.

Key words

Pancreatic secretory trypsin inhibitor (PSTI) Malabsorption syndrome 


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Copyright information

© The Japanese Society of Gastroenterology 1986

Authors and Affiliations

  • Itsuro Nakano
    • 1
  • Akihiro Funakoshi
    • 1
  • Toshinari Kimura
    • 1
  • Yasuji Miyata
    • 1
  • Shunichi Koga
    • 1
  • Hiroshi Ibayashi
    • 1
  1. 1.The Third Department of Internal MedicineKyushu UniversityFukuokaJapan

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