Summary
Serum pancreatic secretory trypsin inhibitor (PSTI) was measured by radioimmunoassay in 5 patients with malabsorption syndrome. The serum level of PSTI was elevated to 123.8 ±25.8 ng/ml (Mean ±SE) in patients with malabsorption syndrome, which was significantly higher than the 16.6 ±0.7 ng/ml level seen in 116 healthy control subjects. Serum PSTI levels in 5 patients with malabsorption syndrome showed inverse correlations with serum levels of cholesterol, cholinesterase and amylase, and not with serum levels of vitamin E, carotene, apoprotein A-IV, albumin, nor with immunoreactive elastase 1, respectively. These results suggest that elevated levels of serum PSTI represent a state of malnutrition due to impaired intestinal absorption.
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Nakano, I., Funakoshi, A., Kimura, T. et al. Elevated levels of serum pancreatic secretory trypsin inhibitor (PSTI) in patients with malabsorption syndrome. Gastroenterol Jpn 21, 617–622 (1986). https://doi.org/10.1007/BF02774490
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DOI: https://doi.org/10.1007/BF02774490