Gastroenterologia Japonica

, Volume 24, Issue 3, pp 332–336 | Cite as

A multi-centre double-blind controlled trial of glucagon and insulin therapy for severe acute hepatitis

  • Hiroshi Oka
  • Kenji Fujiwara
  • Kiwamu Okita
  • Hiromasa Ishii
  • Akira Sakuma
Multi-Center Trial


A cooperative study was conducted to determine the efficacy of one week of treatment with infusion of 1 mg glucagon and 10 units insulin twice daily in severe acute hepatitis. Ninty-eight patients with either prothrombin time less than 60% or thrombotest or hepaplastin test less than 50% of normal were randomly assigned to hormone or placebo treatment. SGOT and SGPT values dropped after treatment with a gradual decrease or increase in total serum bilirubin or cholesterol levels similarly in both groups receiving hormone or placebo. Deranged prothrombin time improved more rapidly in the hormone group than in the placebo group. Glucagon and insulin infusion may stimulate recovery of the liver from injury.

Key words

acute hepatitis glucagon insulin prothrombin time 


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Copyright information

© The Japanese Society of Gastroenterology 1989

Authors and Affiliations

  • Hiroshi Oka
    • 1
  • Kenji Fujiwara
    • 1
  • Kiwamu Okita
    • 2
  • Hiromasa Ishii
    • 3
  • Akira Sakuma
    • 4
  1. 1.First Department of Internal MedicineUniversity of Tokyo Faculty of MedicineTokyoJapan
  2. 2.First Department of Internal MedicineYamaguchi University School of MedicineUbe
  3. 3.Department of Internal MedicineKeio University School of MedicineTokyo
  4. 4.Department of Clinical PharmacologyMedical Research Institute, Tokyo Medical and Dental UniversityTokyoJapan

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