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Gastroenterologia Japonica

, Volume 24, Issue 3, pp 262–269 | Cite as

Non-septic endotoxemia in cirrhotic patients

  • Yoshiaki Yajima
  • Ichiro Fukuda
  • Masao Otsuki
  • Hiroshi Suzuki
  • Kazuo Mori
  • Yoshio Goto
Original Article

Summary

We have found that endotoxemia detected by conventional LCT (limulus colorimetric test) in patients with liver diseases could not be detected by endotoxin-specific LCT at all, and proposed that this β-glucan like activity (BGLA) should be termed as non-septic endotoxemia, distinguishing it from septic endotoxemia seen in gram-negative sepsis. In this study, we investigated non-septic endotoxemia through the clinical course of 8 cirrhotic patients. Non-septic endotoxemia appeared at the onset of DIC but tended to decline in level in the late terminal stage. This phenomenon cannot be consistent with the “spillover” theory which explains the mechanism of endotoxemia without sepsis in liver disease. We think it is an urgent problem to elucidate the nature of BGLA in liver disease, without recourse to the “spillover” theory.

Key words

β-glucan like activity DIC endotoxemia liver cirrhosis non-septic endotoxemia 

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Copyright information

© The Japanese Society of Gastroenterology 1989

Authors and Affiliations

  • Yoshiaki Yajima
    • 1
  • Ichiro Fukuda
    • 1
  • Masao Otsuki
    • 1
  • Hiroshi Suzuki
    • 1
  • Kazuo Mori
    • 1
  • Yoshio Goto
    • 1
  1. 1.Third Department of Internal MedicineTohoku University School of MedicineSendaiJapan

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