Gastroenterologia Japonica

, Volume 24, Issue 6, pp 715–719 | Cite as

A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis

  • Chisato Hirayama
  • Makoto Okumura
  • Kyuichi Tanikawa
  • Michitami Yano
  • Minoru Mizuta
  • Nobuya Ogawa
Multi-Center Trial


The efficacy of Shosaiko-to (SST) on 222 patients with chronic active hepatitis was studied in a double-blind multicenter clinical study. One hundred and sixteen patients received SST in a daily oral dose of 5.4 g for 12 weeks, followed by the same dose for a further 12 weeks. One hundred and six patients received a placebo containing 0.5 g of SST for 12 weeks, followed by a cross-over to SST for a further 12 weeks. Among the liver tests, serum AST and ALT values decreased significantly with the admisnistration of SST. The difference of the mean value between the SST group and the placebo group was significant after 12 weeks. In patients with chronic active type B hepatitis, a tendency towards a decrease of HBeAg and an increase of Anti-HBe antibodies was also observed. No remarkable side effects were noticed.

Key words

chronic active hepatitis Shosaiko-to 


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Copyright information

© The Japanese Society of Castroenterology 1989

Authors and Affiliations

  • Chisato Hirayama
    • 1
  • Makoto Okumura
    • 2
  • Kyuichi Tanikawa
    • 3
  • Michitami Yano
    • 4
  • Minoru Mizuta
    • 5
  • Nobuya Ogawa
    • 6
  1. 1.Second Department of Internal MedicineTottori University School of MedicineYonagoJapan
  2. 2.First Department of Internal MedicineFukuoka University School of MedicineFukuokaJapan
  3. 3.Second Department of Internal MedicineKurume University School of MedicineKurumeJapan
  4. 4.Institute for Clinical ResearchNagasaki Chuo National HospitalNagasakiJapan
  5. 5.Department of MedicineShuto Sougou HospitalYanaiJapan
  6. 6.Department of PharmacologyEhime University School of MedicineEhimeJapan

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