Skip to main content
SpringerLink
Log in

An experimental study on histamine H2-receptor antagonist on calcium, gastrin and histamine induced gastric acid secretion in rat

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

The suppressive effect of histamine H2-receptor antagonist, cimetidine, on gastric secretion was investigated in Ghosh-Schild rat. The study above was done in basal state under infusing normal saline (l ml/h) and stimulated state by histamine-di-chloride (3.5mg/kg-h), tetragastrin (50mcg/kg-h) or calcium chloride (4 mg/kg-h). Dose related increase of cimetidine (1.7, 3.5, 7.0 and 14.0mg/kg-h) were observed and correlated with the degree of inhibition of acid secretion. Cimetidine had a potent inhibitory activity on either basal and stimulated acid output by the agents above. Basal acid secretion was completely abolished by 3.5 mg/kg-h of cimetidine to the level of anacidity. The degree of inhibition by the same dose of cimetidine was different among the agents used as stimulant on acid secretion and it followed in the order of calcium, gastrin and histamine subsequently. This study indicated that histamine H2-receptor participated the gastric secretion induced by either gastrin or calcium other than histamine itself. This fact indicated the important role of endogenous histamine in gastric secretion induced by calcium and gastrin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Magee, DF: Metiamide: An antagonist of histamine-stimulated gastric acid secretion. Ann Surg 182: 627–629, 1975

    Article  PubMed  CAS  Google Scholar 

  2. Mainardi M, Maxell V, Sturdevant RAL, et al: Metiamide, an H2-receptor blocker, as inhibitor of basal and mealstimulated gastric acid secretion in patients with duodenal ulcer. New Eng J Med 291: 373–376, 1974

    Article  PubMed  CAS  Google Scholar 

  3. Konturek SJ, Biernot J, Oleksy J: Effect of metiamide, a Histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin and peptone meal in man. Am J Dig Dis 19: 609–616, 1974

    Article  PubMed  CAS  Google Scholar 

  4. Forrest JAH, Sherman DJC, Spence R, et al: Neutropenia associated with metiamide. Lancet 1: 329–393, 1975

    Google Scholar 

  5. Barbezat GO, Band S: Effect of prolonged cimetidine therapy on gastric acid secretion in man. Gut 19: 151–154, 1978

    Article  PubMed  CAS  Google Scholar 

  6. Frost F, Rahbek I, Rune SJ: Cimetidine in patients with gastric ulcer: a multicentre controlled trial. Brit Med J 2: 795–799, 1977

    Article  PubMed  CAS  Google Scholar 

  7. Rasmussen H: Cell communication, calcium ion and cyclic adenosine monophosphate. Science 170: 1404, 1970

    Article  Google Scholar 

  8. Segawa K, Nakazawa S, Naito Y, et al: The further investigation on gastric acid secretion in the primary hyperparathyroidism. Gastroent Jpn 12: 347–351, 1977

    CAS  Google Scholar 

  9. Segawa K, Nakazawa S, Imai K, et al: Effect of calcium on gastric secretion in man. Jpn J Gastroent 71:151–160, 1974

    CAS  Google Scholar 

  10. Hidano H: An experimental study of calcium effect on gastric secretion. Jpn J Gastroent 75: 1524–1533, 1978

    CAS  Google Scholar 

  11. Gosh MN, Schild HO: Continuous recording of gastric acid in the rat. Br J Pharmcol 13: 54, 1958

    Google Scholar 

  12. Dockray GJ: Molecular evolution of gut hormones: application of comparative studies on the regulation of digestion. Gastroenterology 72: 344–358, 1977

    PubMed  CAS  Google Scholar 

  13. Rosenfeld GC, Jacobson ED, Thompson WJ: Reevaluation of the role of cyclic AMP in histamineinduced gastric acid secretion. Gastroenterology 70: 832–835, 1976

    PubMed  CAS  Google Scholar 

  14. Amer MS: Cyclic AMP and gastric secretion. Am J Dig Dis 17: 945–953, 1972

    Article  PubMed  CAS  Google Scholar 

  15. Sutherland EW, Roll TW: Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem 232: 1077–1091, 1958

    PubMed  CAS  Google Scholar 

  16. Lewin MJM, Soumarmon A, Bonfils S: Receptors for gastrin and histamine in gastric mucosa. In Glass GBJ (ed.): Progress in gastroenterology, Grune & Stratton, New York, 1977

    Google Scholar 

  17. Code CF: Histamine and gastric secretion. Gastroenterology 51: 272, 1966

    PubMed  CAS  Google Scholar 

  18. Black JW, Duncan WAM, Durant CJ, et al: Definition and Antagonism of Histamine H2-receptors. Nature 236:385–390, 1972

    Article  PubMed  CAS  Google Scholar 

  19. Segawa K, Shinozaki F, Nakazawa S, et al: The interaction of gastrin, histamine and secretin in gastric secretion in rat. Igaku-no-Ayumi 75: 170–172, 1970

    CAS  Google Scholar 

  20. Christiansen J, Rehfeld JF, Kirkegoard P: Interaction of calcium, magnesium and gastrin on gastric acid secretion. Gastroenterology 76: 57–61, 1979

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Second Department of Internal Medicine, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, 466, Nagoya, Japan

    Kose Segawa M.D., Saburo Nakazawa M.D., Yasuo Naito M.D., Kenji Imai M.D., Tsuneaki Kachi M.D., Sumihisa Tsukamoto M.D., Manabu Kajikawa M.D., Masafumi Aichi M.D., Eizo Kimoto M.D., Hiroshi Sano M.D., Jun Tominaga M.D., Tomohiro Ichikawa M.D., Takashi Oida M.D. & Toshio Yoshino M.D.

Authors
  1. Kose Segawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Saburo Nakazawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasuo Naito M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenji Imai M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tsuneaki Kachi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sumihisa Tsukamoto M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Manabu Kajikawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masafumi Aichi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Eizo Kimoto M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hiroshi Sano M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jun Tominaga M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Tomohiro Ichikawa M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Takashi Oida M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Toshio Yoshino M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Segawa, K., Nakazawa, S., Naito, Y. et al. An experimental study on histamine H2-receptor antagonist on calcium, gastrin and histamine induced gastric acid secretion in rat. Gastroenterol Jpn 14, 539–544 (1979). https://doi.org/10.1007/BF02773712

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02773712

Key Words

Search

Navigation