Advertisement

Gastroenterologia Japonica

, Volume 12, Issue 2, pp 58–63 | Cite as

Geographical distribution of the subtype of hepatitis b surface antigen in chinese

  • Juei-Low Sung
  • Ding-Shinn Chen
Original Article
  • 13 Downloads

Summary

Using the much more sensitive hemagglutination inhibition assay for subtyping of hepatitis B surface antigen (HBsAg), we examined the determinants a, d, w and r in 192 from 228 HBsAg positive adults who had been found after screening with reversed passive hemagglutination method. Sixty-four subtypable cases were asymptomatic carriers and the remaining 128 were liver disease patients. Among them there was no significant difference of the subtypes, invariably with adw as the main subtype. Geographical difference was evident: adr was the main subtype (78 per cent) among the northern Chinese; while adw was dominant (76 per cent) among the southern Chinese with the Yangtze River as a boundary. Eight of the 18 adr-subtyped northern Chinese were born and live in Taiwan where 91 per cent of HBsAg positive Taiwanese were adw-subtyped. This was an indirect evidence that intra-familial spreading from parents played an important role in hepatitis B virus infection.

KeyWords

subtype of HBsAg 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Levene, C. and Blumberg, B.S.: Additional specificities of Australia-antigen and the possible identification of hepatitis carriers. Nature, 221: 195–196, 1969.PubMedCrossRefGoogle Scholar
  2. 2).
    Le Bouvier, G.L.: The heterogeneity of Australiaantigen. J. Infect. Dis., 123: 671–675, 1971.PubMedGoogle Scholar
  3. 3).
    Bancroft, W.H., Mundon, E.K. and Russel, P.K.: Detection of additional antigenic determinants of hepatitis B antigen. J. Immunol., 109: 842–848, 1972.PubMedGoogle Scholar
  4. 4).
    Mazzur, S., Falker, D. Blumberg, B.S.: Geographical variation of the “w” subtype of Australia antigen. Nature New New Biology, 243: 44–47, 1973.Google Scholar
  5. 5).
    Mayumi, M. and Nakajima, M.: Ergasteric hepatitis from tissue with Australia antigen. Ann. Int. Med., 79: 602–607, 1973.Google Scholar
  6. 6).
    Mosley, J.W., Edwards, V.M., Meihaus, J.E. and Redeker, A.G.: Subdeterminants d and y of hepatitis B antigen as epidemiologic markers. Am. J. Epidemiol., 95: 529–535, 1972.PubMedGoogle Scholar
  7. 7).
    Gordon, I., Berberian, M., Stevenson, D. and Redeker, A.G.: Distribution of hepatitis B antigenic determinants in different forms of viral hepatitis. J. Infect. Dis., 126: 569–573, 1972.PubMedGoogle Scholar
  8. 8).
    Nielsen, J.O., Le Bouvier, G.L., and the Copenhagen Hepatitis Acute Program: Subtypes of Australia antigen among patients and healthy carriers in Copenhagen. New Engl. J. Med., 288: 1257–1261, 1973.PubMedCrossRefGoogle Scholar
  9. 9).
    Feinman, S.V., Berris, B., Sinclair, J.C., Wrobel, D.M., Alter, H.J. and Holland, P.V.: Relation of hepatitis-B-antigen subtypes in symptom-free carriers to geographical origin and liver abnormalities. Lancet, 2: 867–869, 1973.PubMedCrossRefGoogle Scholar
  10. 10).
    Dodd, R.Y., Holland P.V., Ni, L.Y., Smith, H.M. Greenwalt, T.J.: Hepatitis B antigen: regional variation in incidence and subtype ratio in the American Red Cross donor population. Am. J. Epidemiol., 97: 111–115, 1973.PubMedGoogle Scholar
  11. 11).
    Prince, A.M., Brotman, B. and Ikram, H.: Hemagglutination assay: subtyping by hemagglutination inhibition, an ultra-sensitive identity test for HB antigen. Hepatitis and Blood Transfusion, G.N. Vyas, H.A. Perkins and R. Schmid (eds). New York, Grune and Stratton, 1972, pp. 147–154.Google Scholar
  12. 12).
    Imai, M., Yamashita, Y., Miyakawa, Y. and Mayumi, M.: Haemagglutination inhibition assay of the common determinants and subspecificities of Australia antigen. Immunology, 27: 871–878, 1974.PubMedGoogle Scholar
  13. 13).
    Nishioka, K., Hirayama, T., Sekine, T., Okochi, K., Mayumi, M., Sung, J.L., Liu, C.H. and Lin, T.M.: Australia antigen and hepatocellular carcinoma. Alpha-fetoprotein and Hepatoma, Gann Monograph on Cancer Research, No. 14, H. Hirai and T. Miyaji (eds). Tokyo, University of Tokyo Press, 1973, pp. 167–175.Google Scholar
  14. 14).
    Chen, D.S., Sung, J.L., Liaw, Y.F. and Lai, M.Y.: Studies on hepatitis B surface antigen and its antibody. Presented at the fifth anaual meeting of the Gastroenterological Society of the Republic of China, Taipei, Taiwan, May 17–18, 1975.Google Scholar
  15. 15).
    Thaler, H.: The natural history of chronic hepatitis. The Liver and Its Diseases, F. Schaffner, S. Sherlock and C.M. Leevy (eds). New York, Intercontinental Medical Book Corporation, 1974, pp. 207–215.Google Scholar
  16. 16).
    Magnius, L., Espmark, A. and Ringertz, O.: Differences in specificity of Australia-antigen in different Au-positive categories. Acta Pathol. Microbiol. Scand (B), 80: 340–341, 1972.Google Scholar
  17. 17).
    Schober, A., Thomssen, R. and Kaboth, U.: Serologische Subtypen des Hepatitis-B-Antigens (Australia-Antigen). Dtsch. Med. Wochenschr., 97: 1579–1583, 1972.PubMedCrossRefGoogle Scholar
  18. 18).
    Hadziyannis, S. and Le Bouvier, G.L.: Australia antigen subtypes in Greece. Iatriki, 22: 453–457, 1972.Google Scholar
  19. 19).
    Bar-Shany, S., Edwards, V.M., Mosley, J.W. and Bancroft, W.H.: Subtypes of hepatitis B antigen among Israeli blood donors. Vox Sang., 25: 105–112, 1973.PubMedCrossRefGoogle Scholar
  20. 20).
    LeBouvier, G.L.: Seroanalysis by immunodiffusion: the subtypes of type B hepatitis virus. Hepatitis and Blood Transfusion, G.N. Vyas, H.A. Perkins and R. Schmid (eds). New York, Grune and Stratton, 1972, pp. 97–109.Google Scholar
  21. 21).
    Stevens, C.E., Beasley, R.P., Tsui, J. and Lee, W.C.: Vertical transmission of hepatitis B antigen in Taiwan. New Engl. J. Med., 292: 771–774, 1975.PubMedCrossRefGoogle Scholar
  22. 22).
    Beasley, R.P., Tsui, J. and Stevens, C.E.: Hepatitis B antigen occurrence in families in Taiwan. Proceedings of the International Symposium on Hepatitis in Taipei, the Gastroenterological Society of the Republic of China (ed). Taipei, 1974, pp. 27-33.Google Scholar
  23. 23).
    Chen, D.S. and Sung, J.L.: Family clustering of hepatitis B surface antigen. J. Formosan. Med. Assoc. (in press).Google Scholar

Copyright information

© The Japanese Society of Gastroenterology 1977

Authors and Affiliations

  • Juei-Low Sung
    • 1
  • Ding-Shinn Chen
    • 1
  1. 1.Department of Internal MedicineNational Taiwan University HospitalTaipeiRepublic of China

Personalised recommendations