Abstract
Objective
To investigate the expression of Coxsackie and Adenovirus receptor (CAR) in renal-cell carcinoma and the relationship of the CAR to the biological behavior of the carcinomas.
Methods
The immunohistochemical SP method was used to detect the expression of Coxsackie and Adenovirus receptor in 48 cases of renalcell carcinoma and in 12 cases of normal renal tissue 2 cm away from the tumor tissue.
Results
The positive rates of CAR were 100% in 12 cases of para-tu-mor normal renal tissue and 35.4% in 48 cases of renal-cell carcinoma respectively. The difference of CAR expression between them was significant (P<0.05). The grades of the tumor were as follows: 22 in Grade I, 17 in Grade II and 9 in Grade III with the CAR positive rate being 54.5%, 23.5% and 11.1%, respectively. There was a negative correlation between CAR expression and tumor grading (P<0.05). In addition, the number of the cases in stages I to IV were 19, 13, 11 and 5 respectively, with the respective positive rates being 57.9%, 30.8%, 18.2% and 0.0%, i.e. there also was a negative relationship between CAR expression and the stage (P<0.05).
Conclusion
CAR expression is down-regulated in renal-cell carcinoma compared with normal tissue. The level of CAR may be a sensitive predictor of differentiation, invasion and metastasis. Loss of CAR expression correlates with the invasive phenotype in our analysis of renal -cell carcinoma.
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This work was supported by the National Backbone Teachers Fund of Ministry of Education (No.[00]143).
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Zhang, L., He, D., Li, X. et al. Expression and significance of coxsackie and adenovirus receptor in renal-cell carcinoma. Chin. J. Clin. Oncol. 2, 787–790 (2005). https://doi.org/10.1007/BF02772877
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DOI: https://doi.org/10.1007/BF02772877