Clinical Reviews in Allergy & Immunology

, Volume 13, Issue 1, pp 91–99 | Cite as

Evaluation of the obstetrical risks of the antiphospholipid syndrome and therapeutic management

  • P. Edelman
  • A. M. Rouquette


APLS in obstetrics represents a striking model for materno-fetal pathology, and its treatment is essentially preventive. It is necessary to start it very early in the pregnancy and to prolong it a long time during the postpartum period. In association with attentive clinical, echographic (32), and biological followup of the pregnancy, the different combinations of these three drugs lead to very good results in pregnancy outcome without any other adjuvant therapy.


Systemic Lupus Erythematosus Lupic Nephritis Clinical Review Thrombotic Event Immunology Volume 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Nilsson, I. M., Astedt, B., Hedner, U., and Berezin, D. (1975),Acta Med. Scand. 153–159.Google Scholar
  2. 2.
    Soulier, B. J. P. and Boffa, M. C. (1980),Nouv. Presse Med. 9, 859–864.Google Scholar
  3. 3.
    Edelman, P., Rouquette, A. M., Cohen, J., Verdy, E., Cabane, J., and Sureau, C. (1987),Presse Med. 16, 1829–1832.PubMedGoogle Scholar
  4. 4.
    Edelman, P., Rouquette, A. M., Verdy, E., et al. (1986),Hum. Reprod. 1, 295–297.PubMedGoogle Scholar
  5. 5.
    Asherson, R. A. (1988),J. Rheumatol. 15, 1742–1746.PubMedGoogle Scholar
  6. 6.
    Love, P. E. and Santoro, S. A. (1990),Ann. Inter. Med. 112, 682–698.Google Scholar
  7. 7.
    Letsky, A. and De Smiet, M. (1984),Br. J. Heamatol. 57, 543–552.Google Scholar
  8. 8.
    Stirling, Y., Woolf, L., North, W. R. S., Seghatchian, M. J., and Meade, T. W. (1984),Thromb. Haemost. 52, 176–182.PubMedGoogle Scholar
  9. 9.
    Ware Branch, D. (1990),Maternal Seminars Perinatol. 4, 139–146.Google Scholar
  10. 10.
    Le Thi Huong, T. U., Wechsler, B., Edelman, P., et al. (1993),J. Rheumatol. 20, 1229–1232.PubMedGoogle Scholar
  11. 11.
    Lübbe W. F. and Walker, E. B. (1983),Br. J. Obstet. Gynecol. 90, 487–490.Google Scholar
  12. 12.
    Hadi, H. A. and Treadwell E. L. (1990),Obstet. Gynecol. Survey 45, 780–785.CrossRefGoogle Scholar
  13. 13.
    Galve, E., Ordi, J., Barquinero, J., et al. (1992),Ann. Inter. Med. 116, 293–298.Google Scholar
  14. 14.
    Ware Branch, D., Andres, R., Digre, K. B., Rote, N. S., and Scott, J. R. (1989),Obstet. Gynecol. 73, 541–545.Google Scholar
  15. 15.
    Dekker, G. A. and Sibai, B. M. (1993),Am. J. Obstet. Gynecol. 163, 214–227.Google Scholar
  16. 16.
    de Wolf, E., Carreras, L. O., Merman, P., et al. (1982),Am. J. Obstet. Gynecol. 142, 829–834.PubMedGoogle Scholar
  17. 17.
    Harris, E. N., Asherson, R. A., Gharavi, A. E., et al. (1985),Br. J. Haematol. 59, 227–230.PubMedGoogle Scholar
  18. 18.
    Lockshin, M. D., Harpel, P. C., Druzin, M. L., et al. (1985),Arthritis Rheumatol. 28, 58–66.CrossRefGoogle Scholar
  19. 19.
    Rouquette, A. M., Ramanan, T., Sureau, C., and Edelman, P. (1990),Clin. Exp. Rheumatol. 8, 221.Google Scholar
  20. 20.
    Harris, E. N. and Spinnato, J. A. (1991),Am. J. Obstet. Gynecol. 165, 1272–1277.PubMedGoogle Scholar
  21. 21.
    Haddow, J. E., Rote, N. S., Dostal-Johnson, D., et al. (1991),Am. J. Obstet. Gynecol. 165, 1308–1312.PubMedGoogle Scholar
  22. 22.
    Silver, R. K., MacGregor, S. N., Pasternak, J. F., Neely, S. E. (1992),Obstet. Gynecol. 80, 497–499.PubMedGoogle Scholar
  23. 23.
    Contractor, S., Hiatt, M., Kosmin, M., and Kim, H. G., (1992),Am. J. Perinatol. 9, 409, 410.PubMedCrossRefGoogle Scholar
  24. 24.
    Haylett, J. P. and Lynn, R. I. (1980),Kidney Int. 18, 207–220.CrossRefGoogle Scholar
  25. 25.
    Jungers, P., Forget, D., and Henry-Amart, M. (1986),Adv. Nephrol. 15, 103–141.Google Scholar
  26. 26.
    Cowchock, F. S., Reece, A., Balaban, D., Ware Branch, D., and Ploupfe, L. (1992),Am. J. Obstet. Gynecol. 166, 1318–1323.PubMedGoogle Scholar
  27. 27.
    Landy, H. J., Kessler, C., Kelly, W. K., and Weinglod, A. (1992),Am. J. Perinatol. 9, 146–151.PubMedGoogle Scholar
  28. 28.
    Uzan, S., Beaufils, M., Breart, G., Bazin, B., Capitant, C., and Paris, J. (1991),Lancet 337, 1247–1431.CrossRefGoogle Scholar
  29. 29.
    Rosove, M. H., Tabsh, K, Wassertrum, N., Howard, P., Hahn, B. H., and Kalunian, K. (1990),Obstet. Gynecol. 75, 630–634.PubMedGoogle Scholar
  30. 30.
    Edelman, P. (1990),Clin. Exp. Rheumatol. 8, 220.Google Scholar
  31. 31.
    Hasegawa, I., Takakuwa, K., Goto, S., Yamada, K., Sekizuka, N., Kanazawa, K., and Tanaka, K. (1992),Hum. Reprod. 7, 203–207.PubMedGoogle Scholar
  32. 32.
    Caruso, A., De Carolis, S., Ferrazzani, S., Valesini, G., Caforio, L., and Mancuso, S. (1993),Obstet. Gynecol. 82, 970–977.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • P. Edelman
    • 1
  • A. M. Rouquette
    • 2
  1. 1.Department of Gynecology-ObstetricsBichat HospitalParisFrance
  2. 2.Immunology LaboratoryTenon HospitalParisFrance

Personalised recommendations