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Archives of Gynecology and Obstetrics

, Volume 253, Issue 1, pp 15–19 | Cite as

Effects of an oral contraceptive combination containing 0.150 mg desogestrel plus 0.020 mg ethinyl estradiol on healthy premenopausal women

  • D. de Aloysio
  • M. Mauloni
  • A. Roncuzzi
  • P. Altieri
  • F. Bottiglioni
  • G. F. Trossarelli
  • G. Fanizza
  • A. Covelli
Originals

Summary

Twenty-six healthy premenopausal outpatients from the Menopause Clinic of the University of Bologna were treated with a combination pill containing 0.020 mg of ethinyl estradiol and 0.150 mg of desogestrel for one year. Throughout the treatment period, clinical and laboratory monitoring was periodically performed, and women were asked about the occurrence of climacteric symptoms. This formulation relieved climacteric symptoms, and did not adversely affect lipids and clotting factors, except for a slight increase in serum triglycerides. Laboratory data also suggest a beneficial effect on bone metabolism.

Key words

Oral contraceptives Premenopause Climacteric syndrome 

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References

  1. Bottiglioni F, de Aloysio D, Altieri P, Pretolani G, Villecco AS (1991) Contraccezione ormonale e rischio cardiovascolare nella donna in età fertile avanzata. Gli Ospedali della Vita 2: 55–60Google Scholar
  2. de Aloysio D, Bottiglioni F, Mauloni M (1983) Aspetti sintomatologici del climaterio femminile. In: Atti del LXII Congresso della S.I.G.O. Monduzzi, Bologna, pp 21–61Google Scholar
  3. de Aloysio D, Bottiglioni F, Mauloni M, Bargossi A (1983) Aspetti bioumorali del climaterio femminile. In: Atti del LXII Congresso della S.I.G.O. Monduzzi, Bologna, pp 110–181Google Scholar
  4. de Aloysio D, Fabiani AG, Mauloni M, Bottiglioni F (1989) Analysis of the climacteric syndrome. Maturitas 11: 43–53PubMedCrossRefGoogle Scholar
  5. de Aloysio D, Mauloni M, Cappelletto T, Bottiglioni F (1990) Negative calcium balance starts from advanced fertile age to premenopause. In: Proceedings of the III International Symposium on Osteoporosis. Copenhagen, pp 1059–1060Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • D. de Aloysio
    • 1
  • M. Mauloni
    • 1
  • A. Roncuzzi
    • 1
  • P. Altieri
    • 1
  • F. Bottiglioni
    • 1
  • G. F. Trossarelli
    • 2
  • G. Fanizza
    • 3
  • A. Covelli
    • 4
  1. 1.Department of Obstetrics and GynecologyUniversity of BolognaItaly
  2. 2.Department of Obstetrics and GynecologyUniversity of TurinItaly
  3. 3.Department of Obstetrics and GynecologyUniversity of BariItaly
  4. 4.Scientific Development GroupOrganonItaly

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