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Adherence ofCandida albicans to epithelial cells from normal and cancerous urinary bladders

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Abstract

Patients with malignancies are at high risk to develop infections byCandida albicans. We have compared the adherence ofC. albicans isolated from urine cultures to bladder epithelial cells obtained from healthy volunteers and patients with cancer of the bladder. The mean number ofC. albicans adhering per epithelial cell from areas infiltrated from cancer was significantly higher as compared to cells obtained from intact areas of cancerous bladders bladders and from normal bladders. The increased adherence ofC. albicans to cancerous epithelial cell suggests that malignancies are associated with alterations of the epithelial cell surface which render the cells more susceptible to colonization byC. albicans. The increased colonization may predispose these patients toC. albicans infections.

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Authors and Affiliations

  1. Department of Medicine, Section of Infectious Diseases, Patras University Medical School, Patras, Greece

    A. T. Skoutelis, P. E. Lianou, E. Votta, H. P. Bassaris & J. T. Papavassiliou

  2. Department of Microbiology, Athen University Medical School, Athens, Greece

    A. T. Skoutelis, P. E. Lianou, E. Votta, H. P. Bassaris & J. T. Papavassiliou

Authors
  1. A. T. Skoutelis
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  2. P. E. Lianou
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  3. E. Votta
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  4. H. P. Bassaris
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  5. J. T. Papavassiliou
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Skoutelis, A.T., Lianou, P.E., Votta, E. et al. Adherence ofCandida albicans to epithelial cells from normal and cancerous urinary bladders. International Urology and Nephrology 26, 519–522 (1994). https://doi.org/10.1007/BF02767652

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  • DOI: https://doi.org/10.1007/BF02767652

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