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Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 4, pp 388–390 | Cite as

Effects of synthetic C-terminal fragment of interferon-2α on Daudi cells

  • Yu. A. Romashkova
  • A. V. Danilkovich
  • A. N. Valuiskikh
  • V. V. Pershina
  • K. B. Freze
  • G. T. Sukhikh
Experimental Methods For Clinical Practice
  • 16 Downloads

Abstract

Synthetic fragment of human interferon-2α (124th–138th amino acid residue, laboratory code 2438) inhibits the growth of B lymphocytes (Daudi cell line) in a dose-dependent manner. Radiolabeled peptide 2438 binds to specific receptors on the cell surface and competes with interferon-2α for the common binding sites.

Key Words

interferon peptide proliferation binding receptors 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Yu. A. Romashkova
    • 1
  • A. V. Danilkovich
    • 1
  • A. N. Valuiskikh
    • 1
  • V. V. Pershina
    • 1
  • K. B. Freze
    • 1
  • G. T. Sukhikh
    • 1
    • 2
  1. 1.Department of Cellular Physiology and ImmunologyM. V. Lomonosov Moscow State UniversityUSSR
  2. 2.Laboratory of Clinical Immunology, Russian Center for Perinatology, Obstetrics, and GynecologyMinistry of HealthMoscow

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