Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 130, Issue 8, pp 749–751 | Cite as

Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension

  • M. A. Vlasova
  • A. S. Borovik
  • E. N. Timin
  • A. L. Chernyaev
  • L. M. Mikhaleva
  • O. S. Tarasova
  • I. M. Rodionov
General Pathology And Pathophysiology
  • 27 Downloads

Abstract

In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle layer of the vascular wall.

Key Words

renovascular hypertension rats vascular reactivity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. G. Avtondilov,Medical Morphometry [in Russian], Moscow (1990).Google Scholar
  2. 2.
    D. N. Lapshin and V. B. Koshelev,Fiziol. Zh. SSSR,75, 282–286 (1989).PubMedGoogle Scholar
  3. 3.
    B. Folkow,Physiol. Rev.,62, No. 2, 347–503 (1982).PubMedGoogle Scholar
  4. 4.
    P. C. Johnson,Handbook of Physiology, Bethesda (1980), Vol. 2, pp. 409–442.Google Scholar
  5. 5.
    N. Korsgaard and M. J. Mulvany,Hypertension,12, 162–167 (1988).PubMedGoogle Scholar
  6. 6.
    R. M. K. W. Lee and J. S. Smeda,Can. J. Physiol. Pharmacol.,63, 392–401 (1985).PubMedGoogle Scholar
  7. 7.
    V. V. Machkov, O. S. Tarasova, E. N. Timin, and I. M. Rodionov,Acta Physiol. Scand.,161, 41–46 (1997).PubMedCrossRefGoogle Scholar
  8. 8.
    V. V. Machkov, M. A. Vlasova, O. S. Tarasova,et al., Ibid.Acta Physiol. Scand.,163, 331–337 (1998).PubMedCrossRefGoogle Scholar
  9. 9.
    G. A. Meininger and J. P. Trzeciakowski,Am. J. Physiol.,254, H709-H718 (1988).PubMedGoogle Scholar
  10. 10.
    M. J. Mulvany, U. Baandrup, and H. J. C. Gundersen,Circ. Res.,57, 794–800 (1985).PubMedGoogle Scholar
  11. 11.
    G. K. Owens and S. M. Schwartz, Ibid.Circ. Res.,53, 491–501 (1983).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • M. A. Vlasova
    • 1
  • A. S. Borovik
    • 1
  • E. N. Timin
    • 1
  • A. L. Chernyaev
    • 1
    • 2
  • L. M. Mikhaleva
    • 1
    • 2
  • O. S. Tarasova
    • 1
    • 3
  • I. M. Rodionov
    • 1
    • 3
  1. 1.Laboratory of Cybernetics, A. V. Vishnevskii Institute of SurgeryRussian Academy of Medical SciencesUSSR
  2. 2.Laboratory of Ecological and Geographical Pathology, Institute of Human MorphologyRussian Academy of Medical SciencesUSSR
  3. 3.Department of Human and Animal Physiology, Biological FacultyM. V. Lomonosov Moscow State UniversityUSSR

Personalised recommendations