Abstract
In rats with hypertension modeled by the one kidney-one clamp method, constrictory responses of the isolated caudal artery to norepinephrine differed under various perfusion conditions. Vascular reactions in hypertensive rats were more potent at a constant flow rate, and less potent at a constant pressure compared to those in normotensive rats. Previous experiments demonstrated similar changes in constrictory responses of the caudal artery in spontaneously hypertensive rats. It is assumed that these peculiarities of the vascular reactivity during hypertension are determined by thickening of the smooth muscle layer of the vascular wall.
Similar content being viewed by others
References
G. G. Avtondilov,Medical Morphometry [in Russian], Moscow (1990).
D. N. Lapshin and V. B. Koshelev,Fiziol. Zh. SSSR,75, 282–286 (1989).
B. Folkow,Physiol. Rev.,62, No. 2, 347–503 (1982).
P. C. Johnson,Handbook of Physiology, Bethesda (1980), Vol. 2, pp. 409–442.
N. Korsgaard and M. J. Mulvany,Hypertension,12, 162–167 (1988).
R. M. K. W. Lee and J. S. Smeda,Can. J. Physiol. Pharmacol.,63, 392–401 (1985).
V. V. Machkov, O. S. Tarasova, E. N. Timin, and I. M. Rodionov,Acta Physiol. Scand.,161, 41–46 (1997).
V. V. Machkov, M. A. Vlasova, O. S. Tarasova,et al., Ibid.Acta Physiol. Scand.,163, 331–337 (1998).
G. A. Meininger and J. P. Trzeciakowski,Am. J. Physiol.,254, H709-H718 (1988).
M. J. Mulvany, U. Baandrup, and H. J. C. Gundersen,Circ. Res.,57, 794–800 (1985).
G. K. Owens and S. M. Schwartz, Ibid.Circ. Res.,53, 491–501 (1983).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 159–162, August, 2000
Rights and permissions
About this article
Cite this article
Vlasova, M.A., Borovik, A.S., Timin, E.N. et al. Wall thickness and constrictive responses of the caudal artery in rats with renovascular hypertension. Bull Exp Biol Med 130, 749–751 (2000). https://doi.org/10.1007/BF02766084
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02766084