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Bulletin of Experimental Biology and Medicine

, Volume 130, Issue 8, pp 728–730 | Cite as

Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries

  • L. V. Kapilevich
  • Ya. D. Anfinogenova
  • M. B. Baskakov
  • I. V. Kovalev
  • A. V. Nosarev
  • M. A. Medvedev
Physiology
  • 21 Downloads

Abstract

Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

Key Words

pulmonary arteries endothelium nitric oxide 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • L. V. Kapilevich
    • 1
  • Ya. D. Anfinogenova
    • 1
  • M. B. Baskakov
    • 1
  • I. V. Kovalev
    • 1
  • A. V. Nosarev
    • 1
  • M. A. Medvedev
    • 1
  1. 1.Siberian Medical UniversityTomsk

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