Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 1, pp 68–70 | Cite as

Correlation between molecular heterogeneity of ceruloplasmin mRNA and ceruloplasmin isomers synthesized in rat liver

  • N. V. Tsymbalenko
  • T. D. Aleinikova
  • L. V. Puchkova
  • V. S. Gaitskhoki


Molecular heterogeneity of ceruloplasmin mRNA is studied in rat liver polyribosomes. Blot hybridization of RNA with cDNA reveals three molecular forms of ceruloplasmin mRNA differing in the chain length and structure of the 3′-regions. A correlation between these mRNAs and three isoforms of ceruloplasmin, which perform different functions in the copper transport, is established.

Key Words

mRNA ceruloplasmin isoforms rat liver 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • N. V. Tsymbalenko
    • 1
  • T. D. Aleinikova
    • 1
  • L. V. Puchkova
    • 1
  • V. S. Gaitskhoki
    • 1
  1. 1.Department of Molecular Genetics, Institute of Experimental MedicineRussian Academy of Medical SciencesSt. Petersburg

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