Abstract
The degree of guanylate cyclase activation by sodium nitroprusside increases in the presence of high concentrations of thiols, while its activation with diazetine-di-N-oxide derivatives remains unchanged. In contrast to conventional nitrovasodilators, these derivatives induce no tolerance resulting from deficiency or depletion of endogenous thiols.
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References
L. B. Volodarskii and L. A. Tikhonova,Khimiya Geterotsikl. Soedinenii (Chemistry of Heterocyclic Compounds),6, 748–752 (1985).
V. P. Miroshnichenko, O. G. Busygina, and I. S. Severina,Vopr. Med. Khimii, No. 4, 60–66 (1989).
Yu. Yu. Chirkov, I. A. Tyshchuk, and I. S. Severina,Biokhimiya,53, 1520–1526 (1988).
L. J. Ignarro, K. S. Wood, and M. S. Wolin,Adv. Cycl. Nucl. Protein Phorphor. Res.,17, 267–274 (1984).
O. H. Lowry, N. J. Rosenbrough, A. L. Farr, and R. J. Randall,J. Biol. Chem.,193, 265–275 (1951).
D. G. Mazhukin, L. B. Volodarsky, L. A. Tikhonova, and A. Ya. Tikhonov,Mendeleev Commun.,1, 29–30 (1992).
P. I. Morando, E. B. Borghi, L. M. De Scheingart, and M. A. Blesa,J. Chem. Soc., Dalton Trans., 435–440 (1981).
R. M. J. Palmer, A. G. Ferrige, and S. Moncada,Nature,327, 524–526 (1987).
I. S. Severina, I. K. Ryaposova, L. B. Volodarsky,et al., Biochem. Mol. Biol. Intern.,30, No. 2, 357–366 (1993).
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Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 1, pp. 39–42, January, 1997
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Belushkina, N.N., Ryaposova, I.K. & Severina, I.S. The role of thiols in the stimulation of soluble guanylate cyclase by compounds generating nitric oxide. Bull Exp Biol Med 123, 33–36 (1997). https://doi.org/10.1007/BF02764372
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DOI: https://doi.org/10.1007/BF02764372