Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 1, pp 33–36 | Cite as

The role of thiols in the stimulation of soluble guanylate cyclase by compounds generating nitric oxide

  • N. N. Belushkina
  • I. K. Ryaposova
  • I. S. Severina
Biophysics And Biochemistry


The degree of guanylate cyclase activation by sodium nitroprusside increases in the presence of high concentrations of thiols, while its activation with diazetine-di-N-oxide derivatives remains unchanged. In contrast to conventional nitrovasodilators, these derivatives induce no tolerance resulting from deficiency or depletion of endogenous thiols.

Key Words

guanylate cyclase nitrogen oxide, nitrovasodilators 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • N. N. Belushkina
    • 1
  • I. K. Ryaposova
    • 1
  • I. S. Severina
    • 1
  1. 1.Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscow

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