Skip to main content
SpringerLink
Log in

Generation of free oxygen radicals and clastogenesis in bone marrow cells in MRL/1 mice

  • General Pathology And Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The level of chemiluminescence induced by phorbol myristate acetate or opsonized zymosan in the bone marrow cells of 5–6-month-old male MRL/1 mice is significantly higher than that in the same cells of 1–2-month-old mice. The number of chromosome aberrations induced by the prooxidant mutagen dioxydine in bone marrow cellsin vivo is significantly higher in 5–6-month-old MRL/1 mice than in 1–2-month-old mice. It is suggested that these effects are more pronounced in 5–6-month-old animals due to progressive development of rheumatic pathology in this mouse strain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. T. Velichkovskii, L. G. Korkina, and E. B. Suslova,Gig. Truda, No. 5, 31–34 (1983).

    Google Scholar 

  2. Yu. A. Vladimirov and M. P. Sherstnev,Biofizika,24, 98–108 (1989).

    Google Scholar 

  3. A. D. Durnev, O. Yu. Dubrovskaya, E. A. Higarova, and S. B. Seredenin,Khim.-Farm. Zh., No. 11, 1289–1291 (1989).

  4. G. S. Kozlov and S. M. Noskov,Ter. Arkh., No. 8, 121–123 (1985).

  5. G. N. Pleskovskaya,Revmatologiya, No. 4, 38–44 (1991).

  6. S. B. Seredenin and A. D. Durnev,Pharmakological Protection of the Genome [in Russian], Moscow (1992).

  7. R. S. Allen and L. D. Loosen,Biochem. Biophys. Res. Commun.,69, 245–252 (1976).

    Article  PubMed  CAS  Google Scholar 

  8. P. Yu. Byung,Physiol. Rev.,74, 139–162 (1994).

    Google Scholar 

  9. B. J. Dean,Lab. Anim.,3, 157–174 (1969).

    Article  Google Scholar 

  10. B. Dularay,Ann. Rheum. Dis.,49, 661–664 (1990).

    Article  PubMed  CAS  Google Scholar 

  11. I. Emerit and A. M. Michelson,Acta Physiol. Scand., Suppl. 492, 59–65 (1980).

    Google Scholar 

  12. L. Hang, A. N. Theofilopoulos, and F. J. Dixon,J. Exp. Med.,155, 1690–1701 (1982).

    Article  PubMed  CAS  Google Scholar 

  13. Ch. Rordorf-Adam, D. Serban, and A. Pataki,Clin. Exp. Immunol.,61, 509–516 (1985).

    PubMed  CAS  Google Scholar 

  14. H. Sies,Am. J. Med.,91, 31–38 (1991).

    Article  Google Scholar 

  15. R. D. Situnayake,Ann. Rheum. Dis.,50, 81–86 (1991).

    PubMed  CAS  Google Scholar 

  16. C. E. Vaca and M. Harms-Ringdahl,Biochim. Biophys. Acta,1001, 35–43 (1989).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    N. V. Guseva, A. D. Durnev, G. N. Pleskovskaya, T. A. Lisitsina, S. B. Seredenin & V. A. Nasonova

  2. Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow

    N. V. Guseva, A. D. Durnev, G. N. Pleskovskaya, T. A. Lisitsina, S. B. Seredenin & V. A. Nasonova

Authors
  1. N. V. Guseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. D. Durnev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. N. Pleskovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. Lisitsina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. B. Seredenin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. A. Nasonova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 1, pp. 22–25, January, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guseva, N.V., Durnev, A.D., Pleskovskaya, G.N. et al. Generation of free oxygen radicals and clastogenesis in bone marrow cells in MRL/1 mice. Bull Exp Biol Med 123, 17–20 (1997). https://doi.org/10.1007/BF02764367

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02764367

Key Words

Search

Navigation