Generation of free oxygen radicals and clastogenesis in bone marrow cells in MRL/1 mice
- 25 Downloads
The level of chemiluminescence induced by phorbol myristate acetate or opsonized zymosan in the bone marrow cells of 5–6-month-old male MRL/1 mice is significantly higher than that in the same cells of 1–2-month-old mice. The number of chromosome aberrations induced by the prooxidant mutagen dioxydine in bone marrow cellsin vivo is significantly higher in 5–6-month-old MRL/1 mice than in 1–2-month-old mice. It is suggested that these effects are more pronounced in 5–6-month-old animals due to progressive development of rheumatic pathology in this mouse strain.
Key WordsMRL/1 mice autoimmune pathology chemiluminescence chromosome aberrations dioxydine
Unable to display preview. Download preview PDF.
- 1.B. T. Velichkovskii, L. G. Korkina, and E. B. Suslova,Gig. Truda, No. 5, 31–34 (1983).Google Scholar
- 2.Yu. A. Vladimirov and M. P. Sherstnev,Biofizika,24, 98–108 (1989).Google Scholar
- 3.A. D. Durnev, O. Yu. Dubrovskaya, E. A. Higarova, and S. B. Seredenin,Khim.-Farm. Zh., No. 11, 1289–1291 (1989).Google Scholar
- 4.G. S. Kozlov and S. M. Noskov,Ter. Arkh., No. 8, 121–123 (1985).Google Scholar
- 5.G. N. Pleskovskaya,Revmatologiya, No. 4, 38–44 (1991).Google Scholar
- 6.S. B. Seredenin and A. D. Durnev,Pharmakological Protection of the Genome [in Russian], Moscow (1992).Google Scholar
- 8.P. Yu. Byung,Physiol. Rev.,74, 139–162 (1994).Google Scholar
- 11.I. Emerit and A. M. Michelson,Acta Physiol. Scand., Suppl. 492, 59–65 (1980).Google Scholar