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The Indian Journal of Pediatrics

, Volume 62, Issue 5, pp 525–531 | Cite as

Autoimmune hepatitis

  • Eve A. Roberts
Symposium: Hepatology—Part I

Abstract

Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology. However, the disease mechanism remains uncertain. Different types of autoimmune hepatitis are defined on the basis of which autoantibodies are present: anti-smooth muscle (type 1), anti-liver/kidney microsomal (type 2), or anti-soluble liver antigen (type 3). Diseases which may be clinically similar to autoimmune hepatitis must be excluded before the diagnosis of autoimmune hepatitis is established: Wilson’s disease, primary sclerosing cholangitis, chronic hepatitis B or C, and drug-induced liver disease are among the most important entities. Corticosteroids alone or with azathioprine constitute the usual treatment for autoimmune hepatitis. Although some children achieve a complete remission, or even recovery, and can stop immunosuppressive treatment, others require low-dose prednisone treatment indefinitely.

Key words

Autoimmune hepatitis Autoantibodies Anti-smooth muscle antibodies Anti-liver/kidney microsomal antibodies Immunosuppressive treatment Childhood liver disease 

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Copyright information

© Dr. K C Chaudhuri Foundation 1995

Authors and Affiliations

  • Eve A. Roberts
    • 1
  1. 1.Division of Gastroenterology and Nutrition, The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

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