The Indian Journal of Pediatrics

, Volume 59, Issue 2, pp 221–224 | Cite as

Multidrug resistantSalmonella typhi in Delhi

  • L. Dar
  • B. L. Gupta
  • A. Rattan
  • R. A. Bhujwala
  • Shriniwas
Original Articles


In 1990, we isolated 158 strains ofSalmonella typhi from blood cultures of patients suffering from typhoid fever. Seventy nine (50%) of these isolates were found to be simultaneously resistant to chloramphenicol, ampicillin and cotrimoxazole. These strains were also resistant to streptomycin and tetracycline, but sensitive to gentamicin, amikacin and cephalexin. The minimum inhibitory concentrations of chloramphenicol and trimethoprim for a representative number of these strains were found to be >1024 ug/ ml and >128 ug/ml respectively. Majority of the multidrug resistant (MDR) strains tested against cefotaxime (23/23), ciprofloxacin (38/38) and amoxycillin plus clavulanic acid (23/24) were sensitive to these drugs.

Key Words

Salmonella typhi Drug effects Multiresistant 


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  1. 1.
    Agarwal SC. Chloramphenicol resistance of Salmonella species in India, 1959–1961.Bull WHO 1962; 27: 331–353.PubMedGoogle Scholar
  2. 2.
    Panikar CKJ, Vimala KN. Transferable chloramphenicol resistances inS. typhi.Nature 1972; 239: 109–110.CrossRefGoogle Scholar
  3. 3.
    Agarwal KC, Panhotra BR, Mahanta J et al. Typhoid fever due to chloramphenicol resistantS. typhi.Indian J Med Res 1981; 73: 484–488.PubMedGoogle Scholar
  4. 4.
    Kapil A, Agarwal KC, Ayyagiri A et al.Invitro susceptibility of thiamphenicol againstSalmonella typhi.Indian J Med Res 1988; 88: 395–397.PubMedGoogle Scholar
  5. 5.
    Jain S, Chitnis DS, Sham A et al. Outbreak of chloramphenicol resistant typhoid fever.Indian Pediatr 1987; 24: 193–197.PubMedGoogle Scholar
  6. 6.
    Sharma KB. Epidemiology of multi-drug resitant Salmonellae in India.Prov V Nat Cong Indian Assoc Med Micro 1982; 5–9.Google Scholar
  7. 7.
    Goldstein FW, Chumpitz JC, Guevara JM et al. Plasmid-mediated resistance to multiple antibiotics inSalmonella typhi.J Infect Dis 1986; 153: 261–266.PubMedGoogle Scholar
  8. 8.
    Gupta BL, Bhujwala RA, Shriniwas. MultiresistantSalmonella typhi in India.Lancet 1990; ii: 252.Google Scholar
  9. 9.
    Jesudasan MV, Jacob John T. MultiresitantSalmonella typhi in India.Lancet 1990; ii: 252.CrossRefGoogle Scholar
  10. 10.
    Bauer AW, Kirby WMM, Sherris JC et al. Antibiotic susceptibility testing by a standardized single disk method.Am J Clin Pathol 1966; 45: 493–496.PubMedGoogle Scholar
  11. 11.
    Matsen JM. Antibiotic susceptibility tests. In: Sonnewirth AC, Jarett L, eds. Gradwohl'sClinical Laboratory Methods and Diagnosis, Vol. 2 St Louis: The CV Mosby Co, 1980: 1950–1952.Google Scholar
  12. 12.
    Butler T, Ruman SL, Arnolds K. Response of typhoid fever caused by chloramphenicol susceptibile and chloramphenicol resistant strains ofSalmonella typhi to treatment with trimethoprim-sulphameth-oxazole.Rev Infect Dis 1982; 4: 551–561.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1992

Authors and Affiliations

  • L. Dar
    • 1
  • B. L. Gupta
    • 1
  • A. Rattan
    • 1
  • R. A. Bhujwala
    • 1
  • Shriniwas
    • 1
  1. 1.Department of MicrobiologyAll Indian Institute of Medical SciencesNew Delhi

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