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Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 5, pp 334–336 | Cite as

Synthesis and study of the effect of uracil and theophylline derivatives on the glucose transport into rat hepatic cells

  • O. N. Leonov
  • M. L. Tsyrenina
  • E. I. Melnik
  • V. M. Devichenskii
  • L. Yu. Kryukova
  • E. A. Vorontsov
  • S. L. Kuznetsov
  • L. N. Kryukov
Article
  • 37 Downloads

Abstract

A series of uracil and theophylline derivatives was synthesized. 4-Amino-1,3-dimethyl-5-non-anoylaminouracil displayed the most pronounced effect of thein vitro stimulation of the 2-deoxyglucose transport into hepatic rat cells.

Key words

glucose transport hepatocytes insulin theophyllin derivatives uracil derivatives 

Abbreviations

BSA

bovine serum albumin

HEPES

N-(2-hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)

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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • O. N. Leonov
    • 1
  • M. L. Tsyrenina
    • 1
  • E. I. Melnik
    • 1
  • V. M. Devichenskii
    • 1
  • L. Yu. Kryukova
    • 1
  • E. A. Vorontsov
    • 2
  • S. L. Kuznetsov
    • 2
  • L. N. Kryukov
    • 2
  1. 1.Institute of Biological MedicineMoscowRussia
  2. 2.Center of Medical, Biological, and Ecological ProblemsRussian Academy of Natural SciencesMoscowRussia

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