Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 4, pp 217–234 | Cite as

Methods of locating antigenic determinants of proteins with known primary structures

  • R. P. Evstigneeva
  • M. E. Pal’keeva
Review Article


Theoretical and experimental methods for locating antigenic determinants of proteins with known amino acid sequences are discussed. These methods are systematized on the basis of the theoretical approaches applied, and the efficiency of various predictive methods is compared. Some examples of experimental epitope determination for a number of proteins are given.

Key words

antigenic determinant epitope mapping peptide libraries proteins amino acid sequence antigenic structure prediction 



apolipoprotein C-II


apolipoprotein E


the temperature factor


enzyme linked immunosorbent assay


β2-gpI, and gpC3a, glycoproteins gp41, β2-gpI, and gpC3a, respectively


hepatitis E virus


human immunodeficiency virus


human T-cell leukemia virus


multiple antigenic peptide


main histocompatibility complex


the hepatitis E viral protein


the Coxsackie viral protein


structural conservative region


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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  1. 1.Lomonosov State Academy of Fine Chemical TechnologyMoscowRussia
  2. 2.Russian Cardiological Scientific CenterMinistry of Public Health of the Russian FederationMoscowRussia

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