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Methods of locating antigenic determinants of proteins with known primary structures

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Abstract

Theoretical and experimental methods for locating antigenic determinants of proteins with known amino acid sequences are discussed. These methods are systematized on the basis of the theoretical approaches applied, and the efficiency of various predictive methods is compared. Some examples of experimental epitope determination for a number of proteins are given.

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Abbreviations

apoC-II:

apolipoprotein C-II

apoE:

apolipoprotein E

B norm :

the temperature factor

ELISA:

enzyme linked immunosorbent assay

gp41:

β2-gpI, and gpC3a, glycoproteins gp41, β2-gpI, and gpC3a, respectively

HEV:

hepatitis E virus

HIV:

human immunodeficiency virus

HTLV:

human T-cell leukemia virus

MAP:

multiple antigenic peptide

MHC:

main histocompatibility complex

ORF3:

the hepatitis E viral protein

P2-C:

the Coxsackie viral protein

SCR:

structural conservative region

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  1. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, 117571, Moscow, Russia

    R. P. Evstigneeva

  2. Russian Cardiological Scientific Center, Ministry of Public Health of the Russian Federation, Tret’ya Cherepkovskaya ul. 15a, 121552, Moscow, Russia

    M. E. Pal’keeva

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Evstigneeva, R.P., Pal’keeva, M.E. Methods of locating antigenic determinants of proteins with known primary structures. Russ J Bioorg Chem 26, 217–234 (2000). https://doi.org/10.1007/BF02759161

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